UNC7467 is a Novel IP6K Inhibitor for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. (IC50 values: IP6K1 8.9 nM; IP6K2 4.9 nM; IP6K3 1320 nM). Inositol phosphate profiling of the HCT116 colon cancer cell line demonstrates that UNC7467 reduced levels of inositol pyrophosphates by 66−81%, without significantly perturbing levels of other inositol phosphates. Furthermore, intraperitoneal injection of UNC7467 in diet-induced obese mice improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.
MedKoo Cat#: 466187
Name: UNC7467
CAS#: unknown
Chemical Formula: C20H13NO3
Exact Mass: 315.0895
Molecular Weight: 315.33
Elemental Analysis: C, 76.18; H, 4.16; N, 4.44; O, 15.22
The following data is based on the product molecular weight 315.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
