MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464185 | Name: Albendazole-d7
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively). Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.

Chemical Structure

Albendazole-d7
Albendazole-d7
CAS#1287076-43-0 (deuterated_d7)

Theoretical Analysis

MedKoo Cat#: 464185

Name: Albendazole-d7

CAS#: 1287076-43-0 (deuterated_d7)

Chemical Formula: C12H8D7N3O2S

Exact Mass: 272.1324

Molecular Weight: 272.37

Elemental Analysis: C, 52.92; H, 8.14; N, 15.43; O, 11.75; S, 11.77

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 1,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
1287076-43-0 (deuterated_d7) 54965-21-8 75184-71-3 (sulfone) 54029-12-8 (sulfoxide)
Synonym
Albendazole-d7; Albendazole d7;
IUPAC/Chemical Name
methyl (5-((propyl-d7)thio)-1H-benzo[d]imidazol-2-yl)carbamate
InChi Key
HXHWSAZORRCQMX-JOMZKNQJSA-N
InChi Code
InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)/i1D3,3D2,6D2
SMILES Code
COC(NC1=NC2=CC(SC([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])=CC=C2N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 272.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhu L, Kuang X, Zhang G, Liang L, Liu D, Hu B, Xie Z, Li H, Liu H, Ye M, Chen X, Liu J. Albendazole induces immunotherapy response by facilitating ubiquitin- mediated PD-L1 degradation. J Immunother Cancer. 2022 May;10(5):e003819. doi: 10.1136/jitc-2021-003819. PMID: 35577504; PMCID: PMC9115032. 2: Dharnidharka VR, Agrawal M, Dandge VP. Albendazole. Indian Pediatr. 1993 Sep;30(9):1115-8. PMID: 8125597. 3: Curtiss P, Cobos G, Sicco KL, Seminara N. Acute Alopecia Associated With Albendazole Toxicosis. Cutis. 2022 May;109(5):E43-E45. doi: 10.12788/cutis.0548. PMID: 35856765. 4: Garg D, Sharma S. Albendazole for Neurocysticercosis in Children: How Long is Long Enough? Indian Pediatr. 2022 Dec 15;59(12):909-910. PMID: 36511204. 5: Movahedi F, Li L, Gu W, Xu ZP. Nanoformulations of albendazole as effective anticancer and antiparasite agents. Nanomedicine (Lond). 2017 Oct;12(20):2555-2574. doi: 10.2217/nnm-2017-0102. Epub 2017 Sep 28. PMID: 28954575. 6: Albanese G, Venturi C. Albendazole: a new drug for human parasitoses. Dermatol Clin. 2003 Apr;21(2):283-90. doi: 10.1016/s0733-8635(02)00085-2. PMID: 12757251. 7: Koca T, Akcam M. Albendazole-induced autoimmune hepatitis. Indian Pediatr. 2015 Jan;52(1):78-9. PMID: 25638200. 8: Smith AL, Rego LP, Williams R. Albendazole monitoring. Am J Health Syst Pharm. 1997 Feb 1;54(3):319-20. doi: 10.1093/ajhp/54.3.319. PMID: 9028426. 9: Dayan AD. Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. Acta Trop. 2003 May;86(2-3):141-59. doi: 10.1016/s0001-706x(03)00031-7. PMID: 12745134. 10: Oxberry ME, Reynoldson JA, Thompson RC. The binding and distribution of albendazole and its principal metabolites in Giardia duodenalis. J Vet Pharmacol Ther. 2000 Jun;23(3):113-20. doi: 10.1046/j.1365-2885.2000.00254.x. Erratum in: J Vet Pharmacol Ther 2001 Apr;24(2):158-60. PMID: 11110097. 11: Verdugo Thomas F, Tapia Mingo A, Ramírez Montes D, Oporto Uribe S. Hepatitis tóxica por albendazol [Albendazole-induced toxic hepatitis]. Gastroenterol Hepatol. 2015 Aug-Sep;38(7):436-8. Spanish. doi: 10.1016/j.gastrohep.2014.08.001. Epub 2014 Aug 30. PMID: 25179365. 12: Gross U. Treatment of microsporidiosis including albendazole. Parasitol Res. 2003 Jun;90 Supp 1:S14-8. doi: 10.1007/s00436-002-0753-x. Epub 2002 Dec 10. PMID: 12811545. 13: Horton J. Echinococcosis and Albendazole: A Case for Suitable Treatment. Am J Trop Med Hyg. 2018 Oct;99(4):811-812. doi: 10.4269/ajtmh.18-0609. PMID: 30141399; PMCID: PMC6159601. 14: Capece BP, Virkel GL, Lanusse CE. Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications. Vet J. 2009 Sep;181(3):241-50. doi: 10.1016/j.tvjl.2008.11.010. Epub 2009 Jan 4. PMID: 19124257. 15: Auer H, Kollaritsch H, Jüptner J, Aspöck H. Albendazole and pregnancy. Appl Parasitol. 1994 Jun;35(2):146-7. PMID: 8087155. 16: Eriksen JB, Christensen SB, Bauer-Brandl A, Brandl M. Dissolution/Permeation of Albendazole in the Presence of Cyclodextrin and Bile Salts: A Mechanistic In Vitro Study into Factors Governing Oral Bioavailability. J Pharm Sci. 2022 Jun;111(6):1667-1673. doi: 10.1016/j.xphs.2021.11.010. Epub 2021 Nov 20. PMID: 34808218. 17: Paredes AJ, Bruni SS, Allemandi D, Lanusse C, Palma SD. Albendazole nanocrystals with improved pharmacokinetic performance in mice. Ther Deliv. 2018 Feb;9(2):89-97. doi: 10.4155/tde-2017-0090. PMID: 29325510. 18: Permana AD, Paredes AJ, Zanutto FV, Amir MN, Ismail I, Bahar MA, Sumarheni, Palma SD, Donnelly RF. Albendazole Nanocrystal-Based Dissolving Microneedles with Improved Pharmacokinetic Performance for Enhanced Treatment of Cystic Echinococcosis. ACS Appl Mater Interfaces. 2021 Aug 18;13(32):38745-38760. doi: 10.1021/acsami.1c11179. Epub 2021 Aug 5. PMID: 34353029. 19: Schulz JD, Neodo A, Coulibaly JT, Keiser J. Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02489-18. doi: 10.1128/AAC.02489-18. PMID: 30745388; PMCID: PMC6437472. 20: Zhang QL, Lian DD, Zhu MJ, Li XM, Lee JK, Yoon TJ, Lee JH, Jiang RH, Kim CD. Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells. Biomed Res Int. 2019 Jun 9;2019:3689517. doi: 10.1155/2019/3689517. PMID: 31281836; PMCID: PMC6590486.

View History

LY-2940094 tartrate

LY-2940094 tartrate