MedKoo Cat#: 406321 | Name: PF-376304

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-376304 is a nonspecific PI3K inhibitor under development for anti-inflammatory indications. Phosphoinositide 3-kinase (PI3K) is an enzyme fundamental to the regulation of various metabolic processes.

Chemical Structure

PF-376304
PF-376304
CAS#851757-93-2

Theoretical Analysis

MedKoo Cat#: 406321

Name: PF-376304

CAS#: 851757-93-2

Chemical Formula: C17H24N8O3

Exact Mass: 388.1971

Molecular Weight: 388.42

Elemental Analysis: C, 52.57; H, 6.23; N, 28.85; O, 12.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF376304; PF 376304; PF-376304.
IUPAC/Chemical Name
4-(cycloheptyloxy)-2-morpholino-N-(2H-tetrazol-5-yl)pyrimidine-5-carboxamide
InChi Key
KTPKFJPJRYZTMP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H24N8O3/c26-14(19-16-21-23-24-22-16)13-11-18-17(25-7-9-27-10-8-25)20-15(13)28-12-5-3-1-2-4-6-12/h11-12H,1-10H2,(H2,19,21,22,23,24,26)
SMILES Code
O=C(C1=CN=C(N2CCOCC2)N=C1OC3CCCCCC3)NC4=NNN=N4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs
Storage Condition
0 – 4 oC for short term (weeks to 1 month) or -20 oC for long terms (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly.
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
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Preparing Stock Solutions

The following data is based on the product molecular weight 388.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Robertson DG, Datta K, Wells D, Egnash L, Robosky L, Manning M, Rohde C, Reily MD. Metabonomic evaluation of metabolic dysregulation in rats induced by PF376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol. 2007 Dec;20(12):1871-7. Epub 2007 Nov 15. PubMed PMID: 18001061.