YSR734 is a covalent HDAC inhibitor with cellular activity in acute myeloid leukemia and Duchenne muscular dystrophy. YSR734 showed nM potency against HDAC1−3, sub-μM activity in MV4−11 cells, and limited cytotoxicity in MRC-9 fibroblasts. In C2C12 myoblasts, YSR734 activated muscle-specific biomarkers myogenin/Cav3, causing potent differentiation into myotubes (applications in Duchenne Muscular Dystrophy).
MedKoo Cat#: 125732
Name: YSR734
CAS#: N/A
Chemical Formula: C26H23F5N4O5S
Exact Mass: 598.1300
Molecular Weight: 598.55
Elemental Analysis: C, 52.17; H, 3.87; F, 15.87; N, 9.36; O, 13.36; S, 5.36
The following data is based on the product molecular weight 598.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
