(S)-XY-05 is a PARP7 Inhibitor with (IC50: 4.5 nM). (S)-XY-05 showed enhanced selectivity toward PARP7 and improved pharmacokinetic properties (oral bioavailability: 94.60%) compared with RBN-2397 (oral bioavailability: 25.67%). In the CT26 syngeneic mouse model, monotherapy with (S)-XY-05 displayed a strong antitumor effect (TGI: 83%) by activating T-cell-mediated immunity within the tumor microenvironment.
MedKoo Cat#: 125713
Name: (S)-XY-05
CAS#: N/A
Chemical Formula: C20H20F3N7O2
Exact Mass: 447.1600
Molecular Weight: 447.42
Elemental Analysis: C, 53.69; H, 4.51; F, 12.74; N, 21.91; O, 7.15
The following data is based on the product molecular weight 447.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
