XL147-II is an ATP-competitive inhibitor of class I PI3K isoforms. It acts by abrogating Akt and S6 phosphorylation in HER2+ cells and also inducing the expression and phosphorylation of HER3 and other RTKs.
MedKoo Cat#: 562420
Name: XL147-II
CAS#: 956958-53-5
Chemical Formula: C21H16N6O2S2
Exact Mass: 448.0776
Molecular Weight: 448.51
Elemental Analysis: C, 56.24; H, 3.60; N, 18.74; O, 7.13; S, 14.30
The following data is based on the product molecular weight 448.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
