Synonym
L 650719; L-650719; L650719; 6-HTS;
IUPAC/Chemical Name
6-hydroxybenzo[b]thiophene-2-sulfonamide
InChi Key
XRZYWSVMYHEQPN-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H7NO3S2/c9-14(11,12)8-3-5-1-2-6(10)4-7(5)13-8/h1-4,10H,(H2,9,11,12)
SMILES Code
O=S(C1=CC2=CC=C(O)C=C2S1)(N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
229.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Graham SL, Shepard KL, Anderson PS, Baldwin JJ, Best DB, Christy ME, Freedman MB, Gautheron P, Habecker CN, Hoffman JM, et al. Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity. J Med Chem. 1989 Dec;32(12):2548-54. PubMed PMID: 2585443.
2: Bar-Ilan A, Pessah NI, Maren TH. Ocular hypotensive activity and disposition of the topical carbonic anhydrase inhibitor 6-hydroxy-benzo[b]thiophene-2-sulfonamide, L-650,719, in the rabbit. J Ocul Pharmacol. 1989 Summer;5(2):99-110. PubMed PMID: 2754300.
3: Grove J, Gautheron P, Plazonnet B, Sugrue MF. Ocular distribution studies of the topical carbonic anhydrase inhibitors L-643,799 and L-650,719 and related alkyl prodrugs. J Ocul Pharmacol. 1988 Winter;4(4):279-90. PubMed PMID: 3246565.
4: Werner EB, Gerber DS, Yoder YJ. Effect of a topical carbonic anhydrase inhibitor, 6-hydroxybenzo[b]thiophene-2-sulfonamide, on intraocular pressure in normotensive subjects. Can J Ophthalmol. 1987 Oct;22(6):316-9. PubMed PMID: 3322537.
