MedKoo Cat#: 527787 | Name: VXN20903
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VXN20903, also known as TNFalpha-IN-C87 or C87, is a TNF-alpha inhibitor, inhibiting TNF-alpha-induced cytotoxicity in L929 fibroblast cells. VXN20903 has CAS#332420-90-3, was first reported in J.Biol.Chem. 2014, 289 12457. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

VXN20903
VXN20903
CAS#332420-90-3

Theoretical Analysis

MedKoo Cat#: 527787

Name: VXN20903

CAS#: 332420-90-3

Chemical Formula: C24H15ClN6O3S

Exact Mass: 502.0615

Molecular Weight: 502.93

Elemental Analysis: C, 57.32; H, 3.01; Cl, 7.05; N, 16.71; O, 9.54; S, 6.37

Price and Availability

Size Price Availability Quantity
10mg USD 400.00
50mg USD 1,250.00
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Related CAS #
No Data
Synonym
TNFalpha-IN-C87, VXN20903; VXN-20903; VXN 20903; C87.
IUPAC/Chemical Name
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
InChi Key
VELQTEBILFDDQX-XAYXJRQQSA-N
InChi Code
InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,27H/b28-22+
SMILES Code
O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C4=CC=CC=C4)C3=N\NC5=CC=C(Cl)C([N+]([O-])=O)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 502.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ma et al (2014) A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 289 12457 PMID: 24634219