MedKoo Cat#: 406507 | Name: DAT-230

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria.

Chemical Structure

DAT-230
DAT-230
CAS#1504583-00-9

Theoretical Analysis

MedKoo Cat#: 406507

Name: DAT-230

CAS#: 1504583-00-9

Chemical Formula: C20H21NO2S

Exact Mass: 339.1293

Molecular Weight: 339.45

Elemental Analysis: C, 70.77; H, 6.24; N, 4.13; O, 9.43; S, 9.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
DAT230; DAT 230; DAT-230.
IUPAC/Chemical Name
2-methoxy-5-(2-(3-methoxy-4,5-dimethylphenyl)thiophen-3-yl)aniline
InChi Key
NPXKFXXMFDKVTM-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21NO2S/c1-12-9-15(11-19(23-4)13(12)2)20-16(7-8-24-20)14-5-6-18(22-3)17(21)10-14/h5-11H,21H2,1-4H3
SMILES Code
NC1=CC(C2=C(C3=CC(C)=C(C)C(OC)=C3)SC=C2)=CC=C1OC
Appearance
white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
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Preparing Stock Solutions

The following data is based on the product molecular weight 339.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qiao F, Zuo D, Wang H, Li Z, Qi H, Zhang W, Wu Y. DAT-230, a Novel Microtubule Inhibitor, Induced Aberrant Mitosis and Apoptosis in SGC-7901 Cells. Biol Pharm Bull. 2013;36(2):193-201. PubMed PMID: 23370351. 2: Qiao F, Zuo D, Shen X, Qi H, Wang H, Zhang W, Wu Y. DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080. Cancer Chemother Pharmacol. 2012 Aug;70(2):259-70. doi: 10.1007/s00280-012-1907-x. Epub 2012 Jun 30. PubMed PMID: 22752214.