EIDD-036, also known as EPRX-036, is a synthetic, water-soluble analogue of progesterone, a neurosteroid, and the active metabolite of EIDD-1723 (EPRX-01723), a medication developed for the potential treatment of traumatic brain injury.
MedKoo Cat#: 129054
Name: EIDD-036
CAS#: 211302-60-2
Chemical Formula: C21H31NO2
Exact Mass: 329.2400
Molecular Weight: 329.48
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 76.55; H, 9.48; N, 4.25; O, 9.71
The following data is based on the product molecular weight 329.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fritzemeier RG, van der Westhuyzen AE, D'Erasmo M, Sharma SK, Bartsch P,
Hodson LE, Liu K, Wali B, Sayeed I, Liotta DC. Neurotherapeutic Potential of
Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J
Med Chem. 2023 Apr 27;66(8):5397-5414. doi: 10.1021/acs.jmedchem.2c01484. Epub
2023 Apr 7. PMID: 37026870.
2: Sayeed I, Wali B, Guthrie DB, Saindane MT, Natchus MG, Liotta DC, Stein DG.
Development of a novel progesterone analog in the treatment of traumatic brain
injury. Neuropharmacology. 2019 Feb;145(Pt B):292-298. doi:
10.1016/j.neuropharm.2018.09.013. Epub 2018 Sep 14. PMID: 30222982.
3: Wali B, Sayeed I, Guthrie DB, Natchus MG, Turan N, Liotta DC, Stein DG.
Evaluating the neurotherapeutic potential of a water-soluble progesterone analog
after traumatic brain injury in rats. Neuropharmacology. 2016 Oct;109:148-158.
doi: 10.1016/j.neuropharm.2016.05.017. Epub 2016 Jun 4. PMID: 27267687.
