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MedKoo Cat#: 146047 | Name: Umckalin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Umckalin is a bioactive compound extracted from the roots of Pelargonium sidoides, a plant traditionally used in South African herbal medicine. It exhibits antimicrobial, anti-inflammatory, and immunomodulatory properties, making it useful in the treatment of respiratory infections like the common cold and bronchitis. Umckalin works by enhancing the immune response and inhibiting the growth of bacterial pathogens, while also reducing inflammation in the respiratory tract. Its effectiveness in reducing symptoms of respiratory illnesses has led to its use in complementary medicine and as an adjunct to conventional treatments.

Chemical Structure

Umckalin
Umckalin
CAS#43053-62-9

Theoretical Analysis

MedKoo Cat#: 146047

Name: Umckalin

CAS#: 43053-62-9

Chemical Formula: C19H18O11

Exact Mass: 422.0800

Molecular Weight: 422.34

Elemental Analysis: C, 54.03; H, 4.30; O, 41.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Umckalin;
IUPAC/Chemical Name
7-hydroxy-5,6-dimethoxy-2H-chromen-2-one
InChi Key
DVBPETFXQYSHLJ-UHFFFAOYSA-N
InChi Code
1S/C11H10O5/c1-14-10-6-3-4-9(13)16-8(6)5-7(12)11(10)15-2/h3-5,12H,1-2H3
SMILES Code
COC1=C(O)C=C2OC(=O)C=CC2=C1OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 422.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nawrot J, Gornowicz-Porowska J, Budzianowski J, Nowak G, Schroeder G, Kurczewska J. Medicinal Herbs in the Relief of Neurological, Cardiovascular, and Respiratory Symptoms after COVID-19 Infection A Literature Review. Cells. 2022 Jun 11;11(12):1897. doi: 10.3390/cells11121897. PMID: 35741026; PMCID: PMC9220793. 2: Franco L, de Oliveira BH. Determination of umckalin in commercial tincture and phytopreparations containing Pelargonium sidoides by HPLC: comparison of sample preparation procedures. Talanta. 2010 Jun 15;81(4-5):1368-72. doi: 10.1016/j.talanta.2010.02.036. Epub 2010 Feb 18. PMID: 20441909. 3: Sharma D, Yadav JP. An Overview of Phytotherapeutic Approaches for the Treatment of Tuberculosis. Mini Rev Med Chem. 2017;17(2):167-183. doi: 10.2174/1389557516666160505114603. PMID: 27145855. 4: Alossaimi MA, Alzeer MA, Abdel Bar FM, ElNaggar MH. Pelargonium sidoides Root Extract: Simultaneous HPLC Separation, Determination, and Validation of Selected Biomolecules and Evaluation of SARS-CoV-2 Inhibitory Activity. Pharmaceuticals (Basel). 2022 Sep 23;15(10):1184. doi: 10.3390/ph15101184. PMID: 36297296; PMCID: PMC9610410. 5: Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997 Dec;63(6):508-10. doi: 10.1055/s-2006-957752. PMID: 9434601. 6: Shettar PS, Hiremath MB. GC-MS analysis and anti-oxidant activity of bioactive compounds of Simarouba glauca leaf extracts. Nat Prod Res. 2024 Apr 23:1-10. doi: 10.1080/14786419.2024.2344737. Epub ahead of print. PMID: 38651517. 7: Duchow S, Blaschek W, Classen B. Reproduction of the Medicinal Plant Pelargonium sidoides via Somatic Embryogenesis. Planta Med. 2015 Aug;81(12-13):1169-74. doi: 10.1055/s-0035-1545947. Epub 2015 May 8. PMID: 26287694. 8: Mofokeng MM, Prinsloo G, Araya HT, du Plooy CP, Sathekge NR, Amoo SO, Steyn JM. Yield and Metabolite Production of Pelargonium sidoides DC. in Response to Irrigation and Nitrogen Management. Metabolites. 2020 May 27;10(6):219. doi: 10.3390/metabo10060219. PMID: 32471248; PMCID: PMC7345895. 9: Brendler T, Stander MA, van Wyk BE. Stevens' Cure (Umckaloabo)-the vindication of a patent medicine. Front Pharmacol. 2024 Jan 3;14:1294997. doi: 10.3389/fphar.2023.1294997. PMID: 38235116; PMCID: PMC10791834. 10: Abdel Bar FM, Alossaimi MA, Elekhnawy E, Alzeer MAA, Abo Kamer A, Moglad E, ElNaggar MH. Anti-Quorum Sensing and Anti-Biofilm Activity of Pelargonium × hortorum Root Extract against Pseudomonas aeruginosa: Combinatorial Effect of Catechin and Gallic Acid. Molecules. 2022 Nov 14;27(22):7841. doi: 10.3390/molecules27227841. PMID: 36431942; PMCID: PMC9695561. 11: Trun W, Kiderlen AF, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (Eps 7630). Phytomedicine. 2006 Sep;13(8):570-5. doi: 10.1016/j.phymed.2005.07.004. Epub 2005 Nov 2. PMID: 16920512. 12: Chávez JP, David JM, Yang SW, Cordell GA. 24-norhopene derivatives from Diatenopteryx sorbifolia. J Nat Prod. 1997 Sep;60(9):909-11. doi: 10.1021/np970238+. PMID: 9322363. 13: Li J, Lin B, Wang G, Gao H, Qin M. [Chemical constituents of Datura stramonium seeds]. Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(3):319-22. Chinese. PMID: 22568232.