Ketotifen | CAS# 34580-13-7 | Biochemical

MedKoo Cat#: 576209 | Name: Ketotifen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ketotifen is a second-generation noncompetitive H1 antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks.

Chemical Structure

Ketotifen

CAS#34580-13-7

Theoretical Analysis

MedKoo Cat#: 576209

Name: Ketotifen

CAS#: 34580-13-7

Chemical Formula: C19H19NOS

Exact Mass: 309.1187

Molecular Weight: 309.43

Elemental Analysis: C, 73.75; H, 6.19; N, 4.53; O, 5.17; S, 10.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HC 20-511; HSDB 7283; Ketotifen

IUPAC/Chemical Name

10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-

InChi Key

ZCVMWBYGMWKGHF-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3

SMILES Code

CN1CCC(=C2c3ccccc3CC(=O)c4sccc24)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 309.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schwarzer G, Bassler D, Mitra A, Ducharme FM, Forster J. Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children. Cochrane Database Syst Rev. 2004;(1):CD001384. Review. PubMed PMID: 14973969. 2: Pérez-Padilla JR. [Ketotifen (Zaditen and K-Asthmal): a drug with sales disproportionate to its demonstrated effectiveness]. Gac Med Mex. 1999 Mar-Apr;135(2):165-70. Review. Spanish. PubMed PMID: 10327750. 3: Grant SM, Goa KL, Fitton A, Sorkin EM. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs. 1990 Sep;40(3):412-48. Review. Erratum in: Drugs 1991 Feb;41(2):192. PubMed PMID: 2226222. 4: Oehling A, Castillo JG, Gamboa PM. Membrane IgE and adenyl cyclase activity in the dynamics of bronchospasm. Ketotifen as a blocker of antigen action. Allergol Immunopathol (Madr). 1990 Jul-Aug;18(4):237-40. Review. PubMed PMID: 1702264. 5: Nowak D, Magnussen H. [Ketotifen (Zaditen) and disodium cromoglycinic acid (Intal) in the therapy of bronchial asthma]. Prax Klin Pneumol. 1987 Sep;41(9):319-23. Review. German. PubMed PMID: 3124092. 6: Craps L. Prophylaxis of asthma with ketotifen in children and adolescents: a review. Pharmatherapeutica. 1983;3(5):314-26. Review. PubMed PMID: 6405397. 7: Craps L. [Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation]. Allergol Immunopathol (Madr). 1981;Suppl 9:177-90. Review. French. PubMed PMID: 6131598. 8: Doligalska M. [Effect of ketotifen on the immune response in BALB/c mice infected with Trichinella spiralis]. Wiad Parazytol. 2000;46(2):217-24. Review. Polish. PubMed PMID: 16886340. 9: Paquette D, Rothe MJ. Unapproved dermatologic indications for H2 receptor antagonists, cromolyn sodium, and ketotifen. Clin Dermatol. 2000 Jan-Feb;18(1):103-11. Review. PubMed PMID: 10701091. 10: Mancel E, Drouet M, Sabbah A. [Membrane stabilizers (chromones and ketotifen)]. Allerg Immunol (Paris). 1999 Apr;31(4):103-5. Review. French. PubMed PMID: 10370721. 11: Govil YC, Misra PK. Ketotifen. Indian Pediatr. 1992 Jan;29(1):85-9. Review. PubMed PMID: 1601503. 12: Lieberman D, Lieberman D. [Prophylaxis of bronchial asthma--disodium cromoglycate and ketotifen]. Harefuah. 1987 May 1;112(9):462-6. Review. Hebrew. PubMed PMID: 3117649. 13: Warner JO, Goldsworthy SJ. Ketotifen in childhood allergic disease. Clin Allergy. 1982 Oct;12 Suppl:21-7. Review. PubMed PMID: 6814787. 14: Craps L. Ketotifen in the oral prophylaxis of bronchial asthma: a review. Pharmatherapeutica. 1981;3(1):18-35. Review. PubMed PMID: 6119703.