MedKoo Cat#: 127880 | Name: Muscimol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Muscimol is a neurotoxic isoxazole obtained by decarboxylation of Ibotenic Acid. Muscimol is a potent agonist of GABA-A receptors and is used mainly as an experimental tool in animal and tissue studies.

Chemical Structure

Muscimol hydrochloride
Muscimol hydrochloride
CAS#3579-03-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 127880

Name: Muscimol hydrochloride

CAS#: 3579-03-1 (HCl)

Chemical Formula: C4H7ClN2O2

Exact Mass: 150.0196

Molecular Weight: 150.56

Elemental Analysis: C, 31.91; H, 4.69; Cl, 23.55; N, 18.61; O, 21.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Muscimol hydrochloride; Agarin, Agarine, CCRIS 3720, HSDB 6036, Muscimol, Pantherin, Pantherine
IUPAC/Chemical Name
5-(aminomethyl)isoxazol-3(2H)-one hydrochloride
InChi Key
IIDOLBNZAZXSHC-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H6N2O2.ClH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H
SMILES Code
Cl.NCC1=CC(=O)NO1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 150.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Johnston GA. Muscimol as an ionotropic GABA receptor agonist. Neurochem Res. 2014 Oct;39(10):1942-7. doi: 10.1007/s11064-014-1245-y. Epub 2014 Jan 29. Review. PubMed PMID: 24473816. 2: Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec;43(12):1462-8. PubMed PMID: 12460246. 3: King TS, Potter D, Kang IS, Norris C, Chen E, Schenken RS, Javors MA. Concentration-dependent effects of muscimol to enhance pulsatile GnRH release from GT1-7 neurons in vitro. Brain Res. 1999 Apr 3;824(1):56-62. PubMed PMID: 10095042. 4: Jones HE, Balster RL. Muscimol-like discriminative stimulus effects of GABA agonists in rats. Pharmacol Biochem Behav. 1998 Feb;59(2):319-26. PubMed PMID: 9476976.