Sodium picosulfate monohydrate | CAS# 1307301-38-7 | laxative

MedKoo Cat#: 127631 | Name: Sodium picosulfate monohydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium Picosulfate is used for colon cleansing before colonoscopy. The common laxative principle of sodium picosulfate is that the hydrolysis of picosulfate, in contrast to that of bisacodyl, is attributable to the microorganisms of the intestinal flora.

Chemical Structure

Sodium picosulfate monohydrate

CAS# 1307301-38-7 (hydrate)

Theoretical Analysis

MedKoo Cat#: 127631

Name: Sodium picosulfate monohydrate

CAS#: 1307301-38-7 (hydrate)

Chemical Formula: C18H15NNa2O9S2

Exact Mass: 498.9984

Molecular Weight: 499.42

Elemental Analysis: C, 43.29; H, 3.03; N, 2.80; Na, 9.21; O, 28.83; S, 12.84

Price and Availability

Size	Price	Availability
5mg	USD 450.00	2 Weeks
25mg	USD 950.00	2 Weeks
100mg	USD 1,650.00	2 Weeks

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Related CAS #

10040-45-6 (sodium) 1307301-38-7 (hydrate)

Synonym

Sodium picosulfate monohydrate; Sodium picosulfate [USAN]; Sodium Picosulfate; Natrii picosulfas; Picosulfate sodium; Sodium picosulphate; Guttalax; LA 391; Laxidogol;

IUPAC/Chemical Name

sodium (pyridin-2-ylmethylene)bis(4,1-phenylene) bis(sulfate) hydrate

InChi Key

FHYUVJHZGPGDSP-UHFFFAOYSA-L

InChi Code

InChI=1S/C18H15NO8S2.2Na.H2O/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;;1H2/q;2*+1;/p-2

SMILES Code

C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].O.[Na+].[Na+]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 499.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Acute hyponatremia with seizure and mental change after oral sodium picosulfate/magnesium citrate bowel preparation. Ann Coloproctol. 2014 Dec;30(6):290-3. doi: 10.3393/ac.2014.30.6.290. Epub 2014 Dec 31. PubMed PMID: 25580417; PubMed Central PMCID: PMC4286777. 5: Song KH, Suh WS, Jeong JS, Kim DS, Kim SW, Kwak DM, Hwang JS, Kim HJ, Park MW, Shim MC, Koo JI, Kim JH, Shon DH. Effectiveness of Sodium Picosulfate/Magnesium Citrate (PICO) for Colonoscopy Preparation. Ann Coloproctol. 2014 Oct;30(5):222-7. doi: 10.3393/ac.2014.30.5.222. Epub 2014 Oct 28. PubMed PMID: 25360429; PubMed Central PMCID: PMC4213938. 6: Rex DK, DiPalma JA, McGowan J, Cleveland Mv. A comparison of oral sulfate solution with sodium picosulfate: magnesium citrate in split doses as bowel preparation for colonoscopy. Gastrointest Endosc. 2014 Dec;80(6):1113-23. doi: 10.1016/j.gie.2014.05.329. Epub 2014 Jul 12. PubMed PMID: 25028274. 7: Kim HG, Huh KC, Koo HS, Kim SE, Kim JO, Kim TI, Kim HS, Myung SJ, Park DI, Shin JE, Yang DH, Lee SH, Lee JS, Lee CK, Chang DK, Joo YE, Cha JM, Hong SP, Kim HJ. Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial. Gut Liver. 2015 Jul;9(4):494-501. doi: 10.5009/gnl14010. PubMed PMID: 25287163; PubMed Central PMCID: PMC4477993. 8: Leitao K, Grimstad T, Bretthauer M, Holme Ø, Paulsen V, Karlsen L, Isaksen K, Cvancarova M, Aabakken L. Polyethylene glycol vs sodium picosulfate/magnesium citrate for colonoscopy preparation. Endosc Int Open. 2014 Dec;2(4):E230-4. doi: 10.1055/s-0034-1377520. Epub 2014 Oct 24. PubMed PMID: 26135098; PubMed Central PMCID: PMC4423298. 9: Hosoe N, Nakashita M, Imaeda H, Sujino T, Bessho R, Ichikawa R, Inoue N, Kanai T, Hibi T, Ogata H. Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese. J Gastroenterol Hepatol. 2012 Oct;27(10):1617-22. doi: 10.1111/j.1440-1746.2012.07190.x. PubMed PMID: 22646064. 10: Morgan D. Bowel preparation with sodium picosulfate was linked to hyponatremia compared with polyethylene glycol. Ann Intern Med. 2014 Jul 15;161(2):JC12. doi: 10.7326/0003-4819-161-2-201407150-02012. PubMed PMID: 25023266. 11: Ishikawa A, Sugiura K, Sato A, Muro Y, Akiyama M. Drug eruption due to sodium picosulfate. Eur J Dermatol. 2012 May-Jun;22(3):410-1. doi: 10.1684/ejd.2012.1679. PubMed PMID: 22407128. 12: Muñoz-Navas M, Calleja JL, Payeras G, Hervás AJ, Abreu LE, Orive V, Menchén PL, Bordas JM, Armengol JR, Carretero C, Beltrán VP, Alonso-Abreu I, Manteca R, Parra-Blanco A, Carballo F, Herrerías JM, Badiola C. A randomized trial to compare the efficacy and tolerability of sodium picosulfate-magnesium citrate solution vs. 4 L polyethylene glycol solution as a bowel preparation for colonoscopy. Int J Colorectal Dis. 2015 Oct;30(10):1407-16. doi: 10.1007/s00384-015-2307-6. Epub 2015 Jul 16. PubMed PMID: 26179377. 13: Manes G, Repici A, Hassan C; MAGIC-P study group. Randomized controlled trial comparing efficacy and acceptability of split- and standard-dose sodium picosulfate plus magnesium citrate for bowel cleansing prior to colonoscopy. Endoscopy. 2014 Aug;46(8):662-9. doi: 10.1055/s-0034-1365800. Epub 2014 Jul 14. PubMed PMID: 25019969. 14: de Moura DT, Guedes H, Tortoretto V, Arataque TP, de Moura EG, Román JP, Rodela GL, Artifon EL. [Comparison of colon-cleansing methods in preparation for colonoscopy-comparative of solutions of mannitol and sodium picosulfate]. Rev Gastroenterol Peru. 2016 Oct-Dec;36(4):293-297. Spanish. PubMed PMID: 28062864. 15: Suh JP, Choi YS, Lee SH. Education and Imaging. Gastroenterology: acute mucosal injury of esophagus and stomach induced by sodium picosulfate/magnesium citrate for bowel preparation. J Gastroenterol Hepatol. 2014 Aug;29(8):1571. doi: 10.1111/jgh.12633. PubMed PMID: 25073632. 16: Jeon SR, Kim HG, Lee JS, Kim JO, Lee TH, Cho JH, Kim YH, Cho JY, Lee JS. Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate. Int J Colorectal Dis. 2015 Feb;30(2):251-8. doi: 10.1007/s00384-014-2066-9. Epub 2014 Nov 20. PubMed PMID: 25410648. 17: Bertiger G, Jones E, Dahdal DN, Marshall DC, Joseph RE. Serum magnesium concentrations in patients receiving sodium picosulfate and magnesium citrate bowel preparation: an assessment of renal function and electrocardiographic conduction. Clin Exp Gastroenterol. 2015 Jul 28;8:215-24. doi: 10.2147/CEG.S79216. eCollection 2015. PubMed PMID: 26251626; PubMed Central PMCID: PMC4524271. 18: Bertiger G, Bugni J, Barocas M. A comparison of oral sulfate solution with sodium picosulfate and magnesium citrate in split doses as bowel preparation for colonoscopy. Gastrointest Endosc. 2015 Mar;81(3):778. doi: 10.1016/j.gie.2014.09.063. PubMed PMID: 25708773. 19: Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, Bubeck J. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol. 2010 Apr;105(4):897-903. doi: 10.1038/ajg.2010.41. Epub 2010 Feb 23. PubMed PMID: 20179697. 20: Yang Y, Yu J, Lu Y, Xia Y, Zhong D, Chen X. High-sensitivity liquid chromatography-tandem mass spectrometry method for the simultaneous determination of sodium picosulfate and its three major metabolites in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Feb 1;915-916:1-7. doi: 10.1016/j.jchromb.2012.12.007. 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