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MedKoo Cat#: 581126 | Name: Sodium Picosulfate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium Picosulfate is used for colon cleansing before colonoscopy. The common laxative principle of sodium picosulfate is that the hydrolysis of picosulfate, in contrast to that of bisacodyl, is attributable to the microorganisms of the intestinal flora.

Chemical Structure

Sodium Picosulfate
Sodium Picosulfate
CAS#10040-45-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 581126

Name: Sodium Picosulfate

CAS#: 10040-45-6 (sodium)

Chemical Formula: C18H13NNa2O8S2

Exact Mass: 480.9878

Molecular Weight: 481.40

Elemental Analysis: C, 44.91; H, 2.72; N, 2.91; Na, 9.55; O, 26.59; S, 13.32

Price and Availability

Size Price Availability Quantity
10mg USD 350.00
50mg USD 500.00
100mg USD 700.00
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Related CAS #
10040-45-6 (sodium) 1307301-38-7 (hydrate)
Synonym
Sodium Picosulfate; Natrii picosulfas; Picosulfate sodium; Sodium picosulphate; Guttalax; LA 391; Laxidogol;
IUPAC/Chemical Name
4,4'-(2-Picolylidene)bis(phenylsulfuric acid) disodium salt
InChi Key
GOZDTZWAMGHLDY-UHFFFAOYSA-L
InChi Code
InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
SMILES Code
O=S(OC1=CC=C(C(C2=CC=C(OS(=O)([O-])=O)C=C2)C3=NC=CC=C3)C=C1)([O-])=O.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 481.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Arai S, Hanaoka M, Yamauchi S, Baba H, Hanazawa R, Sato H, Hirakawa A, Tokunaga M, Kinugasa Y. Modified oral antibiotics and mechanical bowel preparation (OAMBP) versus conventional OAMBP for sigmoid colon and rectal surgery: A multicenter randomized non-inferiority trial. Ann Gastroenterol Surg. 2024 Jun 20;8(6):1036-1045. doi: 10.1002/ags3.12837. PMID: 39502722; PMCID: PMC11533008. 2: Furio S, Lucarini A, Mennini M, Strisciuglio C, Felici E, Ferretti A, Parisi P, D'Angelo F, Marasco G, Barbara G, Ricciardi L, Piccirillo M, Di Nardo G. Effectiveness and safety of polyethylene-glycol-4000 versus sodium picosulphate plus magnesium oxide and citric acid for bowel cleansing before colonoscopy in children: A systematic review with meta-analysis. J Pediatr Gastroenterol Nutr. 2024 Oct 13. doi: 10.1002/jpn3.12388. Epub ahead of print. PMID: 39400405. 3: Tamai N, Sumiyama K. Optimal bowel preparation for colonoscopy. Dig Endosc. 2024 Sep 4. doi: 10.1111/den.14914. Epub ahead of print. PMID: 39229776. 4: Serradesanferm A, Torá-Rocamora I, Pozo À, Ocaña T, Diaz M, Moreira R, Rivero-Sánchez L, Ortiz O, Carballal S, Moreira L, Vaquero EC, Ordás I, Bayarri C, Daca-Alvarez M, Torres S, Grau J, Balaguer F, Castells A, Pellisé M. Adenoma detection rate and tolerability of 2 ultra-low-volume bowel preparations in screening: a noninferiority randomized controlled trial. Gastrointest Endosc. 2024 Jul 26:S0016-5107(24)03353-4. doi: 10.1016/j.gie.2024.07.007. Epub ahead of print. PMID: 39069266. 5: Shen J, Sheng H, He H, Sun C, Han X, Zhu X, Wang C, Shen R, Ye Q, Yuan X, Zhao Q, Yang N, Wang J, Lu T, Chen D, Chen D, Lin J, Shao X. A randomized prospective study comparing the effect of low-volume bowel preparations for colonoscopy preparation in China. Scand J Gastroenterol. 2024 Sep;59(9):1112-1119. doi: 10.1080/00365521.2024.2383276. Epub 2024 Jul 25. PMID: 39054602. 6: Chatterjee A, Kaur S, Jena A, Patil AN, Dutta U, Sebastian S, Sharma V. Strategies to Improve Colonoscopy Preparation in Inflammatory Bowel Disease. A Systematic Review and Network Meta-analysis of Randomized Trials. J Gastrointestin Liver Dis. 2024 Jun 29;33(2):245-253. doi: 10.15403/jgld-5433. PMID: 38944852. 7: Hori H, Ikezawa N, Tanaka S, Ueda C, Fujisawa M, Hoki S, Tanabe H, Ishida R, Okamoto N, Takayama H, Miyazaki H, Sakaguchi H, Kinoshita M, Abe H, Yoshizaki T, Ooi M, Takao M, Morita Y, Toyonaga T, Kodama Y. Efficacy and safety of same-day preparation with sodium picosulfate plus magnesium citrate on the day of colonoscopy for bowel preparation: Multicenter, single-arm, open-label study. J Gastroenterol Hepatol. 2024 Oct;39(10):2151-2157. doi: 10.1111/jgh.16660. Epub 2024 Jun 20. PMID: 38899400. 8: Whorwell P, Lange R, Scarpignato C. Review article: do stimulant laxatives damage the gut? A critical analysis of current knowledge. Therap Adv Gastroenterol. 2024 Jun 16;17:17562848241249664. doi: 10.1177/17562848241249664. PMID: 38887508; PMCID: PMC11181897. 9: Tan S, Zhang W, Zeng P, Yang Y, Chen S, Li Y, Bian Y, Xu C. Clinical effects of chemical drugs, fecal microbiota transplantation, probiotics, dietary fiber, and acupuncture in the treatment of chronic functional constipation: a systematic review and network meta-analysis. Eur J Gastroenterol Hepatol. 2024 Jul 1;36(7):815-830. doi: 10.1097/MEG.0000000000002786. Epub 2024 May 2. PMID: 38829940. 10: Guan T, Chen S, Chen Y, Wang Y, Yu X, Huang X, Liu Q, Lei H, Yang Q. Simultaneous identification of three emergent stimulant laxative adulterants in slimming foods using only one antibody. Anal Bioanal Chem. 2024 May;416(12):2995-3006. doi: 10.1007/s00216-024-05246-4. Epub 2024 Mar 19. PMID: 38502374. 11: Elkaragy ES, Shamseya MM, Metwally RH, Mansour ER, Lashen SA. Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):800-809. doi: 10.1002/jpn3.12135. Epub 2024 Feb 5. PMID: 38314885. 12: Hotta K, Otake Y, Yamaguchi D, Shimodate Y, Hanabata N, Ikematsu H, Yabuuchi Y, Sano Y, Shimoda R, Sugimoto S, Oba M, Takamaru H, Kimura K, Kishida Y, Takada K, Ito S, Imai K, Hosotani K, Murano T, Yamada M, Shinmura K, Takezawa R, Tomonaga M, Saito Y. Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial. BMC Gastroenterol. 2024 Feb 3;24(1):61. doi: 10.1186/s12876-024-03146-6. PMID: 38310266; PMCID: PMC10837887. 13: van Riswijk MLM, van Keulen KE, Neumann H, Siersema PD. An intraprocedural bowel cleansing system for difficult-to-prepare patients-A multicenter prospective feasibility study. United European Gastroenterol J. 2024 Feb;12(1):56-65. doi: 10.1002/ueg2.12501. Epub 2024 Jan 11. PMID: 38213079; PMCID: PMC10859716. 14: Malkin D, Cohen DL, Richter V, Ariam E, Vosko S, Shirin H, Bermont A. A Novel Model to Predict Inadequate Bowel Preparation Prior to Colonoscopy Incorporating Patients' Reactions to Drinking the Laxative. J Clin Med. 2023 Nov 26;12(23):7335. doi: 10.3390/jcm12237335. PMID: 38068387; PMCID: PMC10707332. 15: Pérez Arellano E, Rodríguez García MªI, Galera Ródenas AB, Flores de Miguel Á, de la Morena Madrigal E. 1-L polyethylene glycol + ascorbic acid versus sodium picosulfate + magnesium citrate bowel preparations for colonoscopy: effectiveness and safety. Rev Esp Enferm Dig. 2024 Apr;116(4):186-192. doi: 10.17235/reed.2023.9785/2023. PMID: 37982567. 16: Suflave - a low-volume colonoscopy preparation. Med Lett Drugs Ther. 2023 Sep 18;65(1685):145-147. doi: 10.58347/tml.2023.1685b. PMID: 37682699. 17: Bacsur P, Rutka M, Asbóth A, Resál T, Szántó K, Jójárt B, Bálint A, Ari E, Ajibola W, Kintses B, Fehér T, Pigniczki D, Bor R, Fábián A, Maléth J, Szepes Z, Farkas K, Molnár T. Effects of bowel cleansing on the composition of the gut microbiota in inflammatory bowel disease patients and healthy controls. Therap Adv Gastroenterol. 2023 Jun 6;16:17562848231174298. doi: 10.1177/17562848231174298. PMID: 37324319; PMCID: PMC10265323. 18: Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023 Jun;164(7):1086-1106. doi: 10.1053/j.gastro.2023.03.214. PMID: 37211380; PMCID: PMC10542656. 19: Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Am J Gastroenterol. 2023 Jun 1;118(6):936-954. doi: 10.14309/ajg.0000000000002227. Epub 2023 May 19. PMID: 37204227; PMCID: PMC10544839. 20: Theunissen F, Lantinga MA, Ter Borg PCJ, Ouwendijk RJT, Siersema PD, Bruno MJ; Trans. IT foundation study group. Efficacy of different bowel preparation regimen volumes for colorectal cancer screening and compliance with European Society of Gastrointestinal Endoscopy performance measures. United European Gastroenterol J. 2023 Jun;11(5):448-457. doi: 10.1002/ueg2.12386. Epub 2023 May 15. PMID: 37190897; PMCID: PMC10256997.