Pemigatinib HCl | INCB054828 | CAS#1513857-77-6 | FGFR inhibitor

MedKoo Cat#: 206195 | Name: Pemigatinib HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.

Chemical Structure

Pemigatinib HCl

CAS#Pemigatinib HCl

Theoretical Analysis

MedKoo Cat#: 206195

Name: Pemigatinib HCl

CAS#: Pemigatinib HCl

Chemical Formula: C24H28ClF2N5O4

Exact Mass: 0.0000

Molecular Weight: 523.97

Elemental Analysis: C, 55.02; H, 5.39; Cl, 6.77; F, 7.25; N, 13.37; O, 12.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1513857-77-6 (free base) Pemigatinib HCl

Synonym

INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828. Pemigatinib HCl; Pemigatinib hydrochloride

IUPAC/Chemical Name

3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(morpholin-4-yl)methyl]-1,3,4,7-tetrahydro-2Hpyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one hydrochloride

InChi Key

JAUWPXUYFRLMAN-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H27F2N5O4.ClH/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26;/h9-11H,4-8,12-13H2,1-3H3,(H,27,28);1H

SMILES Code

O=C1N(CC)C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(F)C(OC)=CC(OC)=C5F.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.