EGFR inhibitor D51 is a potent, wild-type-sparing fourth-generation EGFR inhibitor. It is being investigated for treatment of osimertinib-resistance non-small cell lung cancer (NCSCL), potently inhibiting the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM and suppressing the proliferation of H1975-TM cells with an IC50 value of 14 nM. It shows over 500-fold selectivity against wild-type forms, also inhibiting the EGFRdel19/T790M/C797S mutant and the proliferation of the PC9-TM cell line with IC50 values of 62 and 82 nM.
MedKoo Cat#: EGFR Inhibitor D51
Name: EGFR Inhibitor D51
CAS#: EGFR inhibitor D51
Chemical Formula: C27H27F3N6O2S
Exact Mass: 556.1868
Molecular Weight: 556.61
Elemental Analysis: C, 58.26; H, 4.89; F, 10.24; N, 15.10; O, 5.75; S, 5.76
The following data is based on the product molecular weight 556.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
