LY 377604 is a novel mixed β3-adrenoceptor agonist and β1- and β2-adrenoceptors antagonist. It os a potential antidiabetic and antiobesity agent. In rodent models, LY 377604 increased energy expenditure, fat oxidation, reduced hyperglycaemia and induced lean body mass-sparing weight loss. A phase II study was conducted in the US in obesity.
MedKoo Cat#: 127163
Name: LY-377604 hemisuccinate
CAS#: 204593-36-2 (hemisuccinate)
Chemical Formula: C35H38N4O8
Exact Mass: 642.2690
Molecular Weight: 642.71
Elemental Analysis: C, 65.41; H, 5.96; N, 8.72; O, 19.91
The following data is based on the product molecular weight 642.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
