UNC4219 TFA | CAS#1872382-50-7 | 1872382-49-4

MedKoo Cat#: 527049 | Name: UNC-4219 TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UNC4219 is a negative control compound for UNC3866 (GLXC-07803) which is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains.

Chemical Structure

UNC-4219 TFA

CAS#1872382-50-7 (TFA)

Theoretical Analysis

MedKoo Cat#: 527049

Name: UNC-4219 TFA

CAS#: 1872382-50-7 (TFA)

Chemical Formula: C46H69F3N6O10

Exact Mass: 808.5099

Molecular Weight: 923.09

Elemental Analysis: C, 59.85; H, 7.53; F, 6.17; N, 9.10; O, 17.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1872382-50-7 (TFA) 1872382-49-4 (free base)

Synonym

UNC 4219; UNC-4219; UNC4219

IUPAC/Chemical Name

methyl N2-N-((4-(tert-butyl)benzoyl)-L-phenylalanyl)-N-methyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serinate trifluoroacetic acid

InChi Key

VSMDTYSYZIIMJK-SBXVYEEZSA-N

InChi Code

InChI=1S/C44H68N6O8.C2HF3O2/c1-11-50(12-2)25-17-16-20-34(40(54)48-37(28-51)43(57)58-10)45-41(55)35(26-29(3)4)46-38(52)30(5)49(9)42(56)36(27-31-18-14-13-15-19-31)47-39(53)32-21-23-33(24-22-32)44(6,7)8;3-2(4,5)1(6)7/h13-15,18-19,21-24,29-30,34-37,51H,11-12,16-17,20,25-28H2,1-10H3,(H,45,55)(H,46,52)(H,47,53)(H,48,54);(H,6,7)/t30-,34-,35-,36-,37-;/m0./s1

SMILES Code

OC[C@@H](C(OC)=O)NC([C@H](CCCCN(CC)CC)NC([C@H](CC(C)C)NC([C@H](C)N(C([C@H](CC1=CC=CC=C1)NC(C2=CC=C(C(C)(C)C)C=C2)=O)=O)C)=O)=O)=O.O=C(O)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 923.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7. doi: 10.1038/nchembio.2007. Epub 2016 Jan 25. PubMed PMID: 26807715; PubMed Central PMCID: PMC4755828.