RS-67333 | CAS#160845-95-4 | 5-HT4R agonist

MedKoo Cat#: 562915 | Name: RS-67333

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS 67333 is a potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. RS 67333 HCl is active in vivo, with an intrinsic activity relative to 5-HT of 0.5.

Chemical Structure

RS-67333

CAS#160845-95-4 (free base)

Theoretical Analysis

MedKoo Cat#: 562915

Name: RS-67333

CAS#: 160845-95-4 (free base)

Chemical Formula: C19H29ClN2O2

Exact Mass: 352.1918

Molecular Weight: 352.90

Elemental Analysis: C, 64.67; H, 8.28; Cl, 10.05; N, 7.94; O, 9.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

160845-95-4 (free base) 168986-60-5 (HCl)

Synonym

RS-67333; RS 67333; RS67333;

IUPAC/Chemical Name

1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one

InChi Key

JBHLYIVFFLNISJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3

SMILES Code

ClC1=C(N)C=C(OC)C(C(CCC2CCN(CCCC)CC2)=O)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Giannoni P, Gaven F, de Bundel D, Baranger K, Marchetti-Gauthier E, Roman FS, Valjent E, Marin P, Bockaert J, Rivera S, Claeysen S. Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease. Front Aging Neurosci. 2013 Dec 24;5:96. doi: 10.3389/fnagi.2013.00096. eCollection 2013. PubMed PMID: 24399967; PubMed Central PMCID: PMC3871961. 2: Lelong V, Lhonneur L, Dauphin F, Boulouard M. BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):621-8. Epub 2003 May 8. PubMed PMID: 12736770. 3: Lamirault L, Guillou C, Thal C, Simon H. Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):185-95. PubMed PMID: 12551743. 4: Lamirault L, Simon H. Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. Neuropharmacology. 2001 Dec;41(7):844-53. PubMed PMID: 11684148. 5: Lelong V, Dauphin F, Boulouard M. RS 67333 and D-cycloserine accelerate learning acquisition in the rat. Neuropharmacology. 2001 Sep;41(4):517-22. PubMed PMID: 11543772. 6: Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol. 1995 Aug;115(8):1387-92. PubMed PMID: 8564196; PubMed Central PMCID: PMC1908873.