MedKoo Cat#: 125947 | Name: Mannose 6 phosphate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mannose 6-phosphate (M6P) has type-I integral membrane receptors.

Chemical Structure

Mannose 6 phosphate
Mannose 6 phosphate
CAS#3672-15-9 (free base)

Theoretical Analysis

MedKoo Cat#: 125947

Name: Mannose 6 phosphate

CAS#: 3672-15-9 (free base)

Chemical Formula: C6H13O9P

Exact Mass: 260.0297

Molecular Weight: 260.13

Elemental Analysis: C, 27.70; H, 5.04; O, 55.35; P, 11.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Mannose 6 phosphate; Mannose 6-phosphate; Mannose-6-phosphate; D-mannose 6-phosphate; D-Mannose, 6-(dihydrogen phosphate), monosodium
IUPAC/Chemical Name
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl dihydrogen phosphate
InChi Key
VFRROHXSMXFLSN-KVTDHHQDSA-N
InChi Code
InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/t3-,4-,5-,6-/m1/s1
SMILES Code
O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H](O)C=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 260.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Coutinho MF, Prata MJ, Alves S. Mannose-6-phosphate pathway: a review on its role in lysosomal function and dysfunction. Mol Genet Metab. 2012 Apr;105(4):542-50. doi: 10.1016/j.ymgme.2011.12.012. Epub 2011 Dec 23. PMID: 22266136. 2: Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nat Commun. 2022 Sep 12;13(1):5351. doi: 10.1038/s41467-022-33025-1. PMID: 36096887; PMCID: PMC9468337. 3: Meunier M, Chapuis E, Lapierre L, Auriol P, Paulus C, Elbaum B, Don Simoni E, Sandré J, Auriol D, Scandolera A, Reynaud R. Mannose-6-phosphate complex and improvement in biomechanical properties of the skin. J Cosmet Dermatol. 2021 Jun;20(6):1598-1610. doi: 10.1111/jocd.14000. Epub 2021 Mar 10. PMID: 33580613; PMCID: PMC8251629. 4: Qiao W, Richards CM, Jabs S. LYSET/TMEM251- a novel key component of the mannose 6-phosphate pathway. Autophagy. 2023 Jul;19(7):2143-2145. doi: 10.1080/15548627.2023.2167376. Epub 2023 Jan 22. PMID: 36633450; PMCID: PMC10283412. 5: Dalle Vedove E, Costabile G, Merkel OM. Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy. Adv Healthc Mater. 2018 Jul;7(14):e1701398. doi: 10.1002/adhm.201701398. Epub 2018 May 2. PMID: 29719138; PMCID: PMC6108418. 6: Castonguay AC, Olson LJ, Dahms NM. Mannose 6-phosphate receptor homology (MRH) domain-containing lectins in the secretory pathway. Biochim Biophys Acta. 2011 Sep;1810(9):815-26. doi: 10.1016/j.bbagen.2011.06.016. Epub 2011 Jun 24. PMID: 21723917; PMCID: PMC3150748. 7: Zhang B, Yang X, Li M. LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway. Autophagy. 2023 May;19(5):1596-1598. doi: 10.1080/15548627.2023.2167375. Epub 2023 Jan 16. PMID: 36633445; PMCID: PMC10240974. 8: Sletten ET, Danglad-Flores J, Leichnitz S, Abragam Joseph A, Seeberger PH. Expedited synthesis of mannose-6-phosphate containing oligosaccharides. Carbohydr Res. 2022 Jan;511:108489. doi: 10.1016/j.carres.2021.108489. Epub 2021 Dec 11. PMID: 34922155. 9: Gorelik A, Illes K, Bui KH, Nagar B. Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203518119. doi: 10.1073/pnas.2203518119. Epub 2022 Aug 8. PMID: 35939698; PMCID: PMC9388126.