Synonym
Sodium mannose 6-phosphate; 70442-25-0; Sodium D-mannose 6-phosphate; D-Mannose, 6-(dihydrogen phosphate), monosodium salt;
IUPAC/Chemical Name
sodium (2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl hydrogen phosphate
InChi Key
OBHLNVXMRZXIII-MVNLRXSJSA-M
InChi Code
InChI=1S/C6H13O9P.Na/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;/h1,3-6,8-11H,2H2,(H2,12,13,14);/q;+1/p-1/t3-,4-,5-,6-;/m1./s1
SMILES Code
[Na+].O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H](O)[C@H](O)C=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
282.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Coutinho MF, Prata MJ, Alves S. Mannose-6-phosphate pathway: a review on its
role in lysosomal function and dysfunction. Mol Genet Metab. 2012
Apr;105(4):542-50. doi: 10.1016/j.ymgme.2011.12.012. Epub 2011 Dec 23. PMID:
22266136.
2: Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen
L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M. GCAF(TMEM251) regulates
lysosome biogenesis by activating the mannose-6-phosphate pathway. Nat Commun.
2022 Sep 12;13(1):5351. doi: 10.1038/s41467-022-33025-1. PMID: 36096887; PMCID:
PMC9468337.
3: Meunier M, Chapuis E, Lapierre L, Auriol P, Paulus C, Elbaum B, Don Simoni E,
Sandré J, Auriol D, Scandolera A, Reynaud R. Mannose-6-phosphate complex and
improvement in biomechanical properties of the skin. J Cosmet Dermatol. 2021
Jun;20(6):1598-1610. doi: 10.1111/jocd.14000. Epub 2021 Mar 10. PMID: 33580613;
PMCID: PMC8251629.
4: Qiao W, Richards CM, Jabs S. LYSET/TMEM251- a novel key component of the
mannose 6-phosphate pathway. Autophagy. 2023 Jul;19(7):2143-2145. doi:
10.1080/15548627.2023.2167376. Epub 2023 Jan 22. PMID: 36633450; PMCID:
PMC10283412.
5: Dalle Vedove E, Costabile G, Merkel OM. Mannose and Mannose-6-Phosphate
Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy.
Adv Healthc Mater. 2018 Jul;7(14):e1701398. doi: 10.1002/adhm.201701398. Epub
2018 May 2. PMID: 29719138; PMCID: PMC6108418.
6: Castonguay AC, Olson LJ, Dahms NM. Mannose 6-phosphate receptor homology
(MRH) domain-containing lectins in the secretory pathway. Biochim Biophys Acta.
2011 Sep;1810(9):815-26. doi: 10.1016/j.bbagen.2011.06.016. Epub 2011 Jun 24.
PMID: 21723917; PMCID: PMC3150748.
7: Zhang B, Yang X, Li M. LYSET/TMEM251/GCAF is critical for autophagy and
lysosomal function by regulating the mannose-6-phosphate (M6P) pathway.
Autophagy. 2023 May;19(5):1596-1598. doi: 10.1080/15548627.2023.2167375. Epub
2023 Jan 16. PMID: 36633445; PMCID: PMC10240974.
8: Sletten ET, Danglad-Flores J, Leichnitz S, Abragam Joseph A, Seeberger PH.
Expedited synthesis of mannose-6-phosphate containing oligosaccharides.
Carbohydr Res. 2022 Jan;511:108489. doi: 10.1016/j.carres.2021.108489. Epub 2021
Dec 11. PMID: 34922155.
9: Gorelik A, Illes K, Bui KH, Nagar B. Structures of the mannose-6-phosphate
pathway enzyme, GlcNAc-1-phosphotransferase. Proc Natl Acad Sci U S A. 2022 Aug
16;119(33):e2203518119. doi: 10.1073/pnas.2203518119. Epub 2022 Aug 8. PMID:
35939698; PMCID: PMC9388126.
