MedKoo Cat#: 577525 | Name: MK-5757

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-5757 is an ORL1 antagonist.

Chemical Structure

MK-5757
MK-5757
CAS#919482-44-3

Theoretical Analysis

MedKoo Cat#: 577525

Name: MK-5757

CAS#: 919482-44-3

Chemical Formula: C25H35N3O3

Exact Mass: 425.2678

Molecular Weight: 425.57

Elemental Analysis: C, 70.56; H, 8.29; N, 9.87; O, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-5757; MK 5757; MK5757
IUPAC/Chemical Name
2H-Benzimidazol-2-one, 1-((2R)-2,3-dihydroxypropyl)-1,3-dihydro-3-(1-((1R,3S,4S)-spiro(bicyclo(2.2.1)heptane-2,1'-cyclopropan)-3-ylmethyl)-4-piperidinyl)-
InChi Key
DTAPURRKADLRKH-JYRKZWEQSA-N
InChi Code
InChI=1S/C25H35N3O3/c29-16-20(30)14-27-22-3-1-2-4-23(22)28(24(27)31)19-7-11-26(12-8-19)15-21-17-5-6-18(13-17)25(21)9-10-25/h1-4,17-21,29-30H,5-16H2/t17-,18+,20-,21+/m1/s1
SMILES Code
OC[C@H](O)CN1C(=O)N(C2CCN(C[C@H]3[C@@H]4CC[C@@H](C4)C35CC5)CC2)c6ccccc16
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 425.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Hostetler ED, Sanabria-Bohórquez S, Eng W, Joshi AD, Patel S, Gibson RE, O'Malley S, Krause SM, Ryan C, Riffel K, Bi S, Okamoto O, Kawamoto H, Ozaki S, Ohta H, de Groot T, Bormans G, Depré M, de Hoon J, De Lepeleire I, Reynders T, Cook JJ, Burns HD, Egan M, Cho W, van Laere K, Hargreaves RJ. Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human. Neuroimage. 2013 Mar;68:1-10. doi: 10.1016/j.neuroimage.2012.11.053. Epub 2012 Dec 11. PMID: 23238431.