Synonym
CGS20625; CGS-20625; CGS 20625;
IUPAC/Chemical Name
Cyclohepta(b)pyrazolo(3,4-d)pyridin-3(2H)-one, 5,6,7,8,9,10-hexahydro-2-(4-methoxyphenyl)-
InChi Key
XRUUVUYJUULCBQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19N3O2/c1-23-13-9-7-12(8-10-13)21-18(22)15-11-19-16-6-4-2-3-5-14(16)17(15)20-21/h7-11,19H,2-6H2,1H3
SMILES Code
O=C1N(C2=CC=C(OC)C=C2)N=C3C(CCCCC4)=C4NC=C31
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
309.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hirschberg Y, Oberle RL, Ortiz M, Lau H, Markowska M. Oral absorption of CGS-20625, an insoluble drug, in dogs and man. J Pharmacokinet Biopharm. 1995 Feb;23(1):11-23. doi: 10.1007/BF02353783. PMID: 8576841.
2: Williams M, Bennett DA, Loo PS, Braunwalder AF, Amrick CL, Wilson DE, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW. CGS 20625, a novel pyrazolopyridine anxiolytic. J Pharmacol Exp Ther. 1989 Jan;248(1):89-96. PMID: 2563294.
3: Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol. 2006 Feb;69(2):640-9. doi: 10.1124/mol.105.017236. Epub 2005 Nov 4. PMID: 16272224.
4: Jarvis MF, Bennett DA, Loo PA, Braunwalder AF, Thompson TN, Schmutz M, Yokoyoma N, Wasley JW, Williams M. CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity. Prog Clin Biol Res. 1990;361:477-82. PMID: 1981266.
5: Tang AH, Franklin SR. The discriminative stimulus effects of diazepam in rats at two training doses. J Pharmacol Exp Ther. 1991 Sep;258(3):926-31. PMID: 1679851.
6: Brunner LA, Luders RC. Determination of a potential anxiolytic drug (CGS 20625) in human plasma by high-performance liquid chromatography. J Chromatogr. 1991 Aug 23;568(2):487-93. doi: 10.1016/0378-4347(91)80188-i. PMID: 1686029.
7: Bennett DA. Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions. Physiol Behav. 1987;41(3):241-5. doi: 10.1016/0031-9384(87)90360-x. PMID: 2893398.
8: Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W. Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit. Biochem Pharmacol. 2004 Oct 15;68(8):1621-9. doi: 10.1016/j.bcp.2004.07.020. PMID: 15451405.
