PF-03654764 tosylate | CAS#1337536-85-2 | H3 receptor | HEK293 | antagonist | HEK293

MedKoo Cat#: 125727 | Name: PF-03654764 tosylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-03654764 binds with high affinity to the human H3 receptor and with lower affinity to the rat H3 receptor, in addition to having >1000-fold selectivity versus other human histamine receptor subtypes (H1, H2, and H4). PF-03654764 displayed potent antagonist properties in functional assays measuring cAMP utilizing a reporter gene assay (β-lactamase) in HEK293 cells stably expressing full length human or rat H3 receptors.

Chemical Structure

PF-03654764 tosylate

CAS#1337536-85-2 (tosylate)

Theoretical Analysis

MedKoo Cat#: 125727

Name: PF-03654764 tosylate

CAS#: 1337536-85-2 (tosylate)

Chemical Formula: C27H36F2N2O4S

Exact Mass: 522.2400

Molecular Weight: 522.65

Elemental Analysis: C, 62.05; H, 6.94; F, 7.27; N, 5.36; O, 12.24; S, 6.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

935840-35-0 (free base) 1337536-85-2 (tosylate)

Synonym

PF-03654764 tosylate; UNII-OP970177FN; OP970177FN; 1337536-85-2; Q27285769

IUPAC/Chemical Name

(1r,3r)-3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-isobutylcyclobutane-1-carboxamide 4-methylbenzenesulfonate

InChi Key

BPIHLWHJMOUNOO-VCMDNOCUSA-N

InChi Code

InChI=1S/C20H28F2N2O.C7H8O3S/c1-14(2)12-23-19(25)16-10-20(22,11-16)17-6-5-15(18(21)9-17)13-24-7-3-4-8-24;1-6-2-4-7(5-3-6)11(8,9)10/h5-6,9,14,16H,3-4,7-8,10-13H2,1-2H3,(H,23,25);2-5H,1H3,(H,8,9,10)/t16-,20-;

SMILES Code

CC1=CC=C(C=C1)S(O)(=O)=O.CC(C)CNC(=O)[C@H]2C[C@](F)(C2)C3=CC(F)=C(CN4CCCC4)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 522.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.