A 70450 | CAS# 142928-23-2 | Proteinase Inhibitor

MedKoo Cat#: 571193 | Name: A 70450

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 70450 is an inhibitor of aspartyl proteinase. It can be used as an antifungal agent and may have a role in HIV protease inhibition therapy.

Chemical Structure

A 70450

CAS#142928-23-2

Theoretical Analysis

MedKoo Cat#: 571193

Name: A 70450

CAS#: 142928-23-2

Chemical Formula: C19H39ClN2O2

Exact Mass: 362.2700

Molecular Weight: 362.98

Elemental Analysis: C, 62.87; H, 10.83; Cl, 9.77; N, 7.72; O, 8.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

A 70450; A-70450; A70450

IUPAC/Chemical Name

Cyclohexanehexanamide, delta-amino-N-butyl-gamma-hydroxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR-(alphaR*,gammaS*,deltaS*))-

InChi Key

OSCAGQDAAPBGKK-PWGAQZMISA-N

InChi Code

InChI=1S/C19H38N2O2.ClH/c1-4-5-11-21-19(23)16(14(2)3)13-18(22)17(20)12-15-9-7-6-8-10-15;/h14-18,22H,4-13,20H2,1-3H3,(H,21,23);1H/t16-,17+,18+;/m1./s1

SMILES Code

O=C(NCCCC)[C@@H](C(C)C)C[C@H](O)[C@@H](N)CC1CCCCC1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 362.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stewart K, Abad-Zapatero C. Candida proteases and their inhibition: prospects for antifungal therapy. Curr Med Chem. 2001 Jul;8(8):941-8. Review. PubMed PMID: 11375761. 2: Pranav Kumar SK, Kulkarni VM. Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study. Bioorg Med Chem. 2002 Apr;10(4):1153-70. PubMed PMID: 11836127. 3: Cutfield SM, Dodson EJ, Anderson BF, Moody PC, Marshall CJ, Sullivan PA, Cutfield JF. The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors. Structure. 1995 Nov 15;3(11):1261-71. PubMed PMID: 8591036. 4: Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Oie T, Stewart K, Cutfield SM, Cutfield JF, Foundling SI, Ray TL. Structure of secreted aspartic proteinases from Candida. Implications for the design of antifungal agents. Adv Exp Med Biol. 1998;436:297-313. Review. PubMed PMID: 9561233. 5: Lerner CG, Goldman RC. Stimuli that induce production of Candida albicans extracellular aspartyl proteinase. J Gen Microbiol. 1993 Jul;139(7):1643-51. PubMed PMID: 7690395. 6: Cutfield S, Marshall C, Moody P, Sullivan P, Cutfield J. Crystallization of inhibited aspartic proteinase from Candida albicans. J Mol Biol. 1993 Dec 20;234(4):1266-9. PubMed PMID: 8263928.