Synonym
PZ 177; PZ177; PZ-177
IUPAC/Chemical Name
1H-Pyrazole-3-carboxamide, 1-(3-chlorophenyl)-5-methoxy-N,N-dimethyl-
InChi Key
XVCQBERSJBUIEB-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14ClN3O2/c1-16(2)13(18)11-8-12(19-3)17(15-11)10-6-4-5-9(14)7-10/h4-8H,1-3H3
SMILES Code
O=C(C1=NN(C2=CC=CC(Cl)=C2)C(OC)=C1)N(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
279.72
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tsurumi K, Go K, Fujimura H. [Acute toxicity and the central effect of 1-(m-chlorophenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1976;72(1):31-9. Japanese. PubMed PMID: 986348.
2: Tsurumi K, Abe A, Fujimura H, Asai H, Nagasaka M. [General pharmacological actions of l-(m-chlorophenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1976;72(1):41-52. Japanese. PubMed PMID: 986349.
3: Tsurumi K, Abe A, Shibuya T, Fujimura H. [Anti-edematous action of 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1975 Nov;71(8):833-41. Japanese. PubMed PMID: 1240833.
4: Morikawa M, Inoue M, Yoshida S, Tsuboi M. Effect of 1-(m-chlorophenyl)-3-N,N-dimethyl-carbamoyl-5-methoxypyrazole (PZ-177) on drug-metabolizing enzyme on rat liver. Jpn J Pharmacol. 1976 Oct;26(5):593-8. PubMed PMID: 1087357.
5: Tsurumi K, Mirii I, Nozaki M, Fujimura H. [Anti-inflammatory, analgesic and antipyretic actions of 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1975 Nov;71(8):843-56. Japanese. PubMed PMID: 1082832.
6: Sugiura S, Izumi K, Kato K, Hori M. [Studies on syntheses of pyrazolone and pyrazole derivatives. VI. Isolation and identification of metabolites in rabbit urine dosing 1-(3-chlorophenyl)-3-(N,N-dimethylcarbamoyl)-5-methoxypyrazole (author's transl)]. Yakugaku Zasshi. 1981 Mar;101(3):266-70. Japanese. PubMed PMID: 7299639.
