MedKoo Cat#: 565155 | Name: JZ-5029

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JZ-5029 is an irreversible β-Glucocerebrosidase modulator.

Chemical Structure

JZ-5029
JZ-5029
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 565155

Name: JZ-5029

CAS#: NONE

Chemical Formula: C37H37N5O4

Exact Mass: 615.2846

Molecular Weight: 615.73

Elemental Analysis: C, 72.18; H, 6.06; N, 11.37; O, 10.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
JZ5029; JZ-5029; JZ 5029
IUPAC/Chemical Name
2,5-Dioxopyrrolidin-1-yl 11-(2-((2-(pyridin-3-yl)quinazolin-4-yl)amino)-2,3-dihydro-1H-inden-5-yl)undec-10-ynoate
InChi Key
ABZVRIHLSKDPRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C37H37N5O4/c43-33-19-20-34(44)42(33)46-35(45)16-8-6-4-2-1-3-5-7-12-26-17-18-27-23-30(24-29(27)22-26)39-37-31-14-9-10-15-32(31)40-36(41-37)28-13-11-21-38-25-28/h9-11,13-15,17-18,21-22,25,30H,1-6,8,16,19-20,23-24H2,(H,39,40,41)
SMILES Code
O=C(ON1C(CCC1=O)=O)CCCCCCCCC#CC2=CC3=C(CC(NC4=C5C=CC=CC5=NC(C6=CC=CN=C6)=N4)C3)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 615.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D. β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site. J Am Chem Soc. 2018 May 9;140(18):5914-5924. doi: 10.1021/jacs.7b13003. Epub 2018 Apr 30. PubMed PMID: 29676907; PubMed Central PMCID: PMC6098685.