MedKoo Cat#: 581073 | Name: ZD 0870

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZD 0870, infections caused by fluconazole resistant C. albicans may be successfully treated with ZD0870, higher doses than those used to treat infections due to susceptible yeast may be required.

Chemical Structure

ZD 0870
ZD 0870
CAS#141113-28-2

Theoretical Analysis

MedKoo Cat#: 581073

Name: ZD 0870

CAS#: 141113-28-2

Chemical Formula: C24H20F6N6O2

Exact Mass: 538.1552

Molecular Weight: 538.45

Elemental Analysis: C, 53.54; H, 3.74; F, 21.17; N, 15.61; O, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
ZD 0870; D0870; D 0870; ZD0870;
IUPAC/Chemical Name
(+)-(R)-2-(2,4-Difluorophenyl)-1-(3-((E)-4-(2,2,3,3-tetrafluoropropoxy)styryl)-1,2,4-triazol-1-yl)-3-(1,2,4-triazol-1-yl)propan-2-ol
InChi Key
FZEJTXCSLUORDW-DHXBXMGCSA-N
InChi Code
InChI=1S/C24H20F6N6O2/c25-17-4-7-19(20(26)9-17)23(37,10-35-14-31-13-33-35)11-36-15-32-21(34-36)8-3-16-1-5-18(6-2-16)38-12-24(29,30)22(27)28/h1-9,13-15,22,37H,10-12H2/b8-3+/t23-/m1/s1
SMILES Code
O[C@@](CN1N=CN=C1)(C2=CC=C(F)C=C2F)CN3N=C(/C=C/C4=CC=C(OCC(F)(F)C(F)F)C=C4)N=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 538.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Suzuki M, Kato N, Kanai M, Shibasaki M. Catalytic enantioselective synthesis of key intermediates for triazole antifungal agents. Org Lett. 2005 Jun 23;7(13):2527-30. PubMed PMID: 15957882. 2: Najvar LK, Correa A, James P, Luther MF, Graybill JR. ZD0870 treatment of murine candidiasis caused by fluconazole resistant isolates of Candida albicans. J Antimicrob Chemother. 1996 Oct;38(4):671-7. PubMed PMID: 8937961.