Etoxadrol | NMDA receptor antagonist | CAS#30163-01-0

MedKoo Cat#: 124832 | Name: Etoxadrol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etoxadrol is an NMDA receptor antagonist. It exerts phencyclidine-like properties. Etoxadrol has anticonvulsant and anesthetic activity. Intravenous etoxadrol was clinically tested as an anesthetic.

Chemical Structure

Etoxadrol

CAS#30163-01-0 (free base)

Theoretical Analysis

MedKoo Cat#: 124832

Name: Etoxadrol

CAS#: 30163-01-0 (free base)

Chemical Formula: C16H23NO2

Exact Mass: 261.1700

Molecular Weight: 261.37

Elemental Analysis: C, 73.53; H, 8.87; N, 5.36; O, 12.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

30163-01-0 (free base) 23239-37-4 (HCl)

Synonym

ETOXADROL; Etoxadrol, (+/-)-; Etoxadrol [INN]; RO44G6QT80; SIQ2UWR01K

IUPAC/Chemical Name

2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine

InChi Key

INOYCBNLWYEPSB-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H23NO2/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3

SMILES Code

CCC1(OCC(O1)C2CCCCN2)C3=CC=CC=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 261.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sax M, Wünsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem. 2006;6(7):723-32. doi: 10.2174/156802606776894483. PMID: 16719812. 2: Thurkauf A, Mattson MV, Huguenin PN, Rice KC, Jacobson AE. Etoxadrol-meta- isothiocyanate: a potent, enantioselective, electrophilic affinity ligand for the phencyclidine-binding site. FEBS Lett. 1988 Oct 10;238(2):369-74. doi: 10.1016/0014-5793(88)80514-3. PMID: 2901991. 3: Thurkauf A, Zenk PC, Balster RL, May EL, George C, Carroll FI, Mascarella SW, Rice KC, Jacobson AE, Mattson MV. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. doi: 10.1021/jm00120a004. PMID: 2903930. 4: Hidalgo J, Dileo RM, Rikimaru MT, Guzman RJ, Thompson CR. Etoxadrol (CL-1848C) a new dissociative anesthetic: studies in primates and other species. Anesth Analg. 1971 Mar-Apr;50(2):231-9. PMID: 4994714. 5: Frederickson EL, Longnecker DE, Allen GW. Clinical investigation of a new intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). Anesth Analg. 1976 May-Jun;55(3):335-9. doi: 10.1213/00000539-197605000-00010. PMID: 5921.