Synonym
ETOXADROL HYDROCHLORIDE; ETOXADROL HCL; CL-1848C;
IUPAC/Chemical Name
(S)-2-((2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine hydrochloride
InChi Key
YXNTVNNAXUKHQM-CLUYDPBTSA-N
InChi Code
InChI=1S/C16H23NO2.ClH/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14;/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3;1H/t14-,15+,16-;/m0./s1
SMILES Code
[H][C@]1([C@@]2(CCCCN2)[H])CO[C@@](O1)(C3=CC=CC=C3)CC.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
297.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sax M, Wünsch B. Relationships between the structure of dexoxadrol and
etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem.
2006;6(7):723-32. doi: 10.2174/156802606776894483. PMID: 16719812.
2: Thurkauf A, Mattson MV, Huguenin PN, Rice KC, Jacobson AE. Etoxadrol-meta-
isothiocyanate: a potent, enantioselective, electrophilic affinity ligand for
the phencyclidine-binding site. FEBS Lett. 1988 Oct 10;238(2):369-74. doi:
10.1016/0014-5793(88)80514-3. PMID: 2901991.
3: Thurkauf A, Zenk PC, Balster RL, May EL, George C, Carroll FI, Mascarella SW,
Rice KC, Jacobson AE, Mattson MV. Synthesis, absolute configuration, and
molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J
Med Chem. 1988 Dec;31(12):2257-63. doi: 10.1021/jm00120a004. PMID: 2903930.
4: Hidalgo J, Dileo RM, Rikimaru MT, Guzman RJ, Thompson CR. Etoxadrol
(CL-1848C) a new dissociative anesthetic: studies in primates and other species.
Anesth Analg. 1971 Mar-Apr;50(2):231-9. PMID: 4994714.
5: Frederickson EL, Longnecker DE, Allen GW. Clinical investigation of a new
intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). Anesth
Analg. 1976 May-Jun;55(3):335-9. doi: 10.1213/00000539-197605000-00010. PMID:
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