12-HHT | BLT2 agonist

MedKoo Cat#: 128341 | Name: 12-HHT

Description:

WARNING: This product is for research use only, not for human or veterinary use.

12-HHT is a BLT2 agonist.

Chemical Structure

12-HHT

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128341

Name: 12-HHT

CAS#: N/A

Chemical Formula: C17H28O3

Exact Mass: 280.2038

Molecular Weight: 280.41

Elemental Analysis: C, 72.82; H, 10.07; O, 17.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

12-HHT; 12HHT; 12 HHT

IUPAC/Chemical Name

(S,5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoic acid

InChi Key

KUKJHGXXZWHSBG-WBGSEQOASA-N

InChi Code

InChI=1S/C17H28O3/c1-2-3-10-13-16(18)14-11-8-6-4-5-7-9-12-15-17(19)20/h5-8,11,14,16,18H,2-4,9-10,12-13,15H2,1H3,(H,19,20)/b7-5-,8-6+,14-11+/t16-/m0/s1

SMILES Code

OC(CCC/C=C\C/C=C/C=C/[C@@H](O)CCCCC)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 280.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Storniolo CE, Pequera M, Company F, Moreno JJ. 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) induces cell growth and improves barrier function through BLT2 interaction in intestinal epithelial Caco-2 cell cultures. Biochem Pharmacol. 2021 Aug;190:114663. doi: 10.1016/j.bcp.2021.114663. Epub 2021 Jun 20. PMID: 34161796. 2: Giusti F, Casiraghi M, Point E, Damian M, Rieger J, Bon CL, Pozza A, Moncoq K, Banères JL, Catoire LJ. Structure of the agonist 12-HHT in its BLT2 receptor- bound state. Sci Rep. 2020 Feb 14;10(1):2630. doi: 10.1038/s41598-020-59571-6. PMID: 32060341; PMCID: PMC7021728. 3: Al-Samkari H, Kasthuri RS, Parambil JG, Albitar HA, Almodallal YA, Vázquez C, Serra MM, Dupuis-Girod S, Wilsen CB, McWilliams JP, Fountain EH, Gossage JR, Weiss CR, Latif MA, Issachar A, Mei-Zahav M, Meek ME, Conrad M, Rodriguez-Lopez J, Kuter DJ, Iyer VN. An international, multicenter study of intravenous bevacizumab for bleeding in hereditary hemorrhagic telangiectasia: the InHIBIT- Bleed study. Haematologica. 2021 Aug 1;106(8):2161-2169. doi: 10.3324/haematol.2020.261859. PMID: 32675221; PMCID: PMC8327711. 4: Okuno T, Yokomizo T. Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106502. doi: 10.1016/j.prostaglandins.2020.106502. Epub 2020 Oct 16. PMID: 33075476. 5: Leguina-Ruzzi A, Ortiz Diban R, Velarde V. The 12-HHT/BLT2/NO Axis Is Associated to the Wound Healing and Skin Condition in Different Glycaemic States. Med Sci (Basel). 2019 Apr 24;7(4):65. doi: 10.3390/medsci7040065. PMID: 31022982; PMCID: PMC6524016. 6: Okuno T, Yokomizo T. Biological functions of 12(S)-hydroxyheptadecatrienoic acid as a ligand of leukotriene B₄ receptor 2. Inflamm Regen. 2018 Oct 29;38:29. doi: 10.1186/s41232-018-0087-4. PMID: 30397418; PMCID: PMC6205785. 7: Rohlfing AK, Kremser M, Schaale D, Dicenta-Baunach V, Laspa Z, Fu X, Zizmare L, Sigle M, Harm T, Münzer P, Pelzer A, Borst O, Trautwein C, Feil R, Müller K, Castor T, Lämmerhofer M, Gawaz MP. cGMP modulates hemin-mediated platelet death. Thromb Res. 2024 Feb;234:63-74. doi: 10.1016/j.thromres.2023.12.008. Epub 2023 Dec 21. PMID: 38171216. 8: Okuno T. [Identification of the old and new lipid mediator, 12-HHT and the role in skin wound healing]. Seikagaku. 2015 Feb;87(1):125-8. Japanese. PMID: 26571566. 9: Yasukawa K, Okuno T, Ogawa N, Kobayashi Y, Yokomizo T. Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. J Biochem. 2023 Mar 31;173(4):293-305. doi: 10.1093/jb/mvac105. PMID: 36539331. 10: Ding X, Yan F, Wang W, Qin J, Luo L. Integration of transcriptomics and metabolomics identify biomarkers of aberrant lipid metabolism in ulcerative colitis. Int Immunopharmacol. 2024 Apr 20;131:111865. doi: 10.1016/j.intimp.2024.111865. Epub 2024 Mar 14. PMID: 38489972.