FM04 is a novel potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM). It interacts with Q1193 and I1115 in the nucleotide-binding domain 2 (NBD2) of human P-gp, which disrupts the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction, thus inhibiting P-gp.
MedKoo Cat#: 130543
Name: FM04
CAS#: FM04
Chemical Formula: C26H25NO4
Exact Mass: 415.1784
Molecular Weight: 415.49
Elemental Analysis: C, 75.16; H, 6.07; N, 3.37; O, 15.40
The following data is based on the product molecular weight 415.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
