MedKoo Cat#: 592598 | Name: Racemic Naproxen
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Racemic Naproxen is a biochemical.

Chemical Structure

Racemic Naproxen
Racemic Naproxen
CAS#23981-80-8

Theoretical Analysis

MedKoo Cat#: 592598

Name: Racemic Naproxen

CAS#: 23981-80-8

Chemical Formula: C14H14O3

Exact Mass: 230.0943

Molecular Weight: 230.26

Elemental Analysis: C, 73.03; H, 6.13; O, 20.84

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Synonym
Racemic Naproxen; DL-Naproxen; DL Naproxen
IUPAC/Chemical Name
2-(6-Methoxy-2-naphthyl)propionic acid
InChi Key
CMWTZPSULFXXJA-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
SMILES Code
CC(C1=CC=C2C=C(OC)C=CC2=C1)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 230.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang W, Gong J, Zhao J, Zhang H, Wen W, Zhao Z, Li YJ, Wang J, Huang CZ, Gao PF. Integration of Wallach's Rule into Intermolecular Charge Transfer: A Visual Strategy for Chiral Purification. Adv Sci (Weinh). 2024 Jul 16:e2403249. doi: 10.1002/advs.202403249. Epub ahead of print. PMID: 39013078. 2: Chen T, Li H, Shi X, Imbrogno J, Zhao D. Robust Homochiral Polycrystalline Metal-Organic Framework Membranes for High-Performance Enantioselective Separation. J Am Chem Soc. 2024 May 29;146(21):14433-14438. doi: 10.1021/jacs.4c04164. Epub 2024 May 17. PMID: 38757701. 3: Chen W, Qiu X, Chen Y, Ke J, Ji Y, Chen J. Supramolecular Interaction Modulation in Thermosensitive Composites: Enantiomeric Recognition and Chiral Site Regeneration. Anal Chem. 2024 Apr 9;96(14):5580-5588. doi: 10.1021/acs.analchem.4c00040. Epub 2024 Mar 26. PMID: 38532617. 4: Kodama K, Obata M, Hirose T. Enantioseparation via Chiral Supramolecular Gels Comprising Ambidextrous Gelators Based on β-Peptide-type Primary Amines. Chempluschem. 2024 Aug;89(8):e202400021. doi: 10.1002/cplu.202400021. Epub 2024 Mar 22. PMID: 38445837. 5: Ma Z, Shang P, Liu D, Nie Y, Liu Y, Guo X, Wei B, Bai L, Qiao X. Preparation and chromatographic performance of chiral peptide-based stationary phases for enantiomeric separation. Chirality. 2023 Sep;35(9):636-644. doi: 10.1002/chir.23564. Epub 2023 Mar 23. PMID: 36951148. 6: Bukhari AAH. Preparation of molecularly imprinted silica particles with amino functionality for chiral separation of (±)-naproxen. Chirality. 2023 May;35(5):311-322. doi: 10.1002/chir.23541. Epub 2023 Feb 7. PMID: 36751029. 7: Sun W, Qiu H, You H, Chen B, Fang L, Qian J, Tong S. Degree and distribution of substitution of hydroxypropyl-β-cyclodextrin in enantioselective liquid- liquid extraction and countercurrent chromatographic enantioseparation. J Chromatogr A. 2023 Jan 4;1687:463684. doi: 10.1016/j.chroma.2022.463684. Epub 2022 Nov 26. PMID: 36502644. 8: Cao S, Xie C, Ma Q, Wang S, Zhang J, Wang Z. Enantioselective separation of nonsteroidal anti-inflammatory drugs with amylose tris(3-chloro-5-methylphenylcarbamate) stationary phase in HPLC with a focus on enantiomeric quality control in six pharmaceutical formulations containing racemic mixtures or single stereoisomers. Chirality. 2021 Dec;33(12):938-950. doi: 10.1002/chir.23369. Epub 2021 Oct 15. PMID: 34651345. 9: Graham GG, Scott KF. Limitations of drug concentrations used in cell culture studies for understanding clinical responses of NSAIDs. Inflammopharmacology. 2021 Oct;29(5):1261-1278. doi: 10.1007/s10787-021-00871-2. Epub 2021 Sep 12. PMID: 34510275. 10: Červinka C, Fulem M. Structure and Glass Transition Temperature of Amorphous Dispersions of Model Pharmaceuticals with Nucleobases from Molecular Dynamics. Pharmaceutics. 2021 Aug 13;13(8):1253. doi: 10.3390/pharmaceutics13081253. PMID: 34452214; PMCID: PMC8400648. 11: Zhang S, Cheng M, Dhinakaran MK, Sun Y, Li H. Enantioselective Antiport in Asymmetric Nanochannels. ACS Nano. 2021 Aug 24;15(8):13148-13154. doi: 10.1021/acsnano.1c02630. Epub 2021 Jul 28. PMID: 34319088. 12: Liu X, Zhao M, Fan X, Fu Y. Enhanced Production of (S)-2-arylpropionic Acids by Protein Engineering and Whole-Cell Catalysis. Front Bioeng Biotechnol. 2021 Jul 7;9:697677. doi: 10.3389/fbioe.2021.697677. PMID: 34307324; PMCID: PMC8293918. 13: Ozyilmaz E, Ascioglu S, Yilmaz M. Calix[4]arene tetracarboxylic acid-treated lipase immobilized onto metal-organic framework: Biocatalyst for ester hydrolysis and kinetic resolution. Int J Biol Macromol. 2021 Apr 1;175:79-86. doi: 10.1016/j.ijbiomac.2021.02.003. Epub 2021 Feb 4. PMID: 33548316. 14: Jin Y, Sun W, Lv H, Tong S. Spectral study on inclusion interaction and enantiorecognition of 2-aryl carboxylic acids with hydroxypropyl-β-cyclodextrin. Chirality. 2020 Oct;32(10):1257-1263. doi: 10.1002/chir.23276. Epub 2020 Aug 3. PMID: 32743855. 15: Çakmak R, Topal G, Çınar E. Covalent Immobilization of Candida rugosa Lipase on Epichlorohydrin-Coated Magnetite Nanoparticles: Enantioselective Hydrolysis Studies of Some Racemic Esters and HPLC Analysis. Appl Biochem Biotechnol. 2020 Aug;191(4):1411-1431. doi: 10.1007/s12010-020-03274-1. Epub 2020 Feb 27. PMID: 32103473. 16: Y de la Pena MH, Herrera RC, Vazquez ALR. An exploratory study of enantioselective behavior of Sol-Gel encapsulated human serum albumin using frontal analysis. Pak J Pharm Sci. 2019 Nov;32(6):2717-2724. PMID: 31969306. 17: Chen T, Tan H, Chen Q, Gu L, Wei Z, Liu H. Toward High-Efficient Chiral Separation Using Hierarchically Porous HROP@Silica-Gel-Sheet Composite. ACS Appl Mater Interfaces. 2019 Dec 26;11(51):48402-48411. doi: 10.1021/acsami.9b17657. Epub 2019 Dec 16. PMID: 31794664. 18: Salgın S, Çakal M, Salgın U. Kinetic resolution of racemic naproxen methyl ester by magnetic and non-magnetic cross-linked lipase aggregates. Prep Biochem Biotechnol. 2020;50(2):148-155. doi: 10.1080/10826068.2019.1679178. Epub 2019 Oct 24. PMID: 31647366. 19: Singh M, Sethi S, Bhushan R. Liquid chromatographic methods for separation, determination, and bioassay of enantiomers of etodolac: A review. J Sep Sci. 2020 Jan;43(1):18-30. doi: 10.1002/jssc.201900649. Epub 2019 Aug 23. PMID: 31389172. 20: Neale PA, Branch A, Khan SJ, Leusch FDL. Evaluating the enantiospecific differences of non-steroidal anti-inflammatory drugs (NSAIDs) using an ecotoxicity bioassay test battery. Sci Total Environ. 2019 Dec 1;694:133659. doi: 10.1016/j.scitotenv.2019.133659. Epub 2019 Jul 29. PMID: 31386950.