Isofetamid | CAS#875915-78-9 | NSAID

MedKoo Cat#: 146009 | Name: Isofetamid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isofetamid is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce inflammation, pain, and fever. It works by inhibiting cyclooxygenase (COX) enzymes, which are responsible for producing prostaglandins that promote inflammation and pain. By blocking COX-1 and COX-2, Isofetamid provides relief in conditions like rheumatoid arthritis, osteoarthritis, and acute musculoskeletal pain. Its anti-inflammatory and analgesic properties make it useful in managing inflammatory disorders, although its use requires caution due to potential side effects with prolonged use.

Chemical Structure

Isofetamid

CAS#875915-78-9

Theoretical Analysis

MedKoo Cat#: 146009

Name: Isofetamid

CAS#: 875915-78-9

Chemical Formula: C20H25NO3S

Exact Mass: 359.1600

Molecular Weight: 359.48

Elemental Analysis: C, 66.82; H, 7.01; N, 3.90; O, 13.35; S, 8.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Isofetamid; IKF-5411; IKF 5411;

IUPAC/Chemical Name

N-(1-(4-isopropoxy-2-methylphenyl)-2-methyl-1-oxopropan-2-yl)-3-methylthiophene-2-carboxamide

InChi Key

WMKZDPFZIZQROT-UHFFFAOYSA-N

InChi Code

1S/C20H25NO3S/c1-12(2)24-15-7-8-16(14(4)11-15)18(22)20(5,6)21-19(23)17-13(3)9-10-25-17/h7-12H,1-6H3,(H,21,23)

SMILES Code

CC(C)OC1=CC=C(C(=O)C(C)(C)NC(=O)C2=C(C)C=CS2)C(C)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 359.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 32078478. 5: EFSA (European Food Safety Authority); Bellisai G, Bernasconi G, Carrasco Cabrera L, Castellan I, Del Aguila M, Ferreira L, Santonja GG, Greco L, Jarrah S, Leuschner R, Perez JM, Miron I, Nave S, Pedersen R, Reich H, Ruocco S, Santos M, Scarlato AP, Theobald A, Tiramani M, Verani A. Modification of the existing maximum residue levels for isofetamid in certain salad plants. EFSA J. 2023 Aug 9;21(8):e08206. doi: 10.2903/j.efsa.2023.8206. PMID: 37564192; PMCID: PMC10411322. 6: Lu Z, Fang N, Zhang Z, Hou Z, Lu Z, Li Y. Residue analysis of fungicides fenpicoxamid, isofetamid, and mandestrobin in cereals using zirconium oxide disposable pipette extraction clean-up and ultrahigh-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2020 Jun 7;1620:461004. doi: 10.1016/j.chroma.2020.461004. Epub 2020 Feb 28. PMID: 32143875. 7: Zhou L, Liu Y, Kong F, Jia S, Wang Q, Wang Z, Zhang H, Huang X. Sensitivity of Botrytis cinerea from Vineyards to Boscalid, Isofetamid, and Pydiflumetofen in Shandong Province, China. Phytopathology. 2024 May;114(5):1068-1074. doi: 10.1094/PHYTO-10-23-0369-KC. Epub 2024 Apr 17. PMID: 38105240. 8: EFSA (European Food Safety Authority); Bellisai G, Bernasconi G, Brancato A, Carrasco Cabrera L, Ferreira L, Giner G, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Reich H, Ruocco S, Santos M, Scarlato AP, Theobald A, Vagenende B, Verani A. Modification of the existing maximum residue levels for isofetamid in raspberries, blackberries and dewberries. EFSA J. 2021 Jun 24;19(6):e06677. doi: 10.2903/j.efsa.2021.6677. PMID: 34194577; PMCID: PMC8223124. 9: Yamashita M, Fraaije B. Non-target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici. Pest Manag Sci. 2018 Mar;74(3):672-681. doi: 10.1002/ps.4761. Epub 2017 Nov 23. PMID: 29024365; PMCID: PMC5814837. 10: Popko JT Jr, Sang H, Lee J, Yamada T, Hoshino Y, Jung G. Resistance of Sclerotinia homoeocarpa Field Isolates to Succinate Dehydrogenase Inhibitor Fungicides. Plant Dis. 2018 Dec;102(12):2625-2631. doi: 10.1094/PDIS-12-17-2025-RE. Epub 2018 Oct 11. PMID: 30307834. 11: Alzohairy SA, Heger L, Nikzainalalam N, Miles TD. Cross-Resistance of Succinate Dehydrogenase Inhibitors (SDHI) in Botrytis cinerea and Development of Molecular Diagnostic Tools for SDHI Resistance Detection. Phytopathology. 2023 Jun;113(6):998-1009. doi: 10.1094/PHYTO-09-22-0346-R. Epub 2023 Aug 4. PMID: 36596212. 12: European Food Safety Authority (EFSA); Brancato A, Brocca D, Carrasco Cabrera L, De Lentdecker C, Ferreira L, Greco L, Jarrah S, Kardassi D, Leuschner R, Lythgo C, Medina P, Miron I, Molnar T, Nougadere A, Pedersen R, Reich H, Sacchi A, Santos M, Stanek A, Sturma J, Tarazona J, Theobald A, Vagenende B, Villamar-Bouza L. Modification of the existing maximum residue levels for isofetamid in tomatoes, peppers, aubergines, okra and cucurbits with edible peel. EFSA J. 2018 May 14;16(5):e05264. doi: 10.2903/j.efsa.2018.5264. PMID: 32625901; PMCID: PMC7009367. 13: Förster H, Luo Y, Hou L, Adaskaveg JE. Mutations in Sdh Gene Subunits Confer Different Cross-Resistance Patterns to SDHI Fungicides in Alternaria alternata Causing Alternaria Leaf Spot of Almond in California. Plant Dis. 2022 Jul;106(7):1911-1918. doi: 10.1094/PDIS-09-21-1913-RE. Epub 2022 Jun 13. PMID: 34978879. 14: Kerhoas M, Carteret J, Huchet L, Jouan E, Huc L, Vée ML, Fardel O. Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors. Ecotoxicol Environ Saf. 2024 May;276:116261. doi: 10.1016/j.ecoenv.2024.116261. Epub 2024 Apr 3. PMID: 38574644. 15: Oliveira MS, Cordova LG, Peres NA. Efficacy and Baseline Sensitivity of Succinate-Dehydrogenase-Inhibitor Fungicides for Management of Colletotrichum Crown Rot of Strawberry. Plant Dis. 2020 Nov;104(11):2860-2865. doi: 10.1094/PDIS-01-20-0083-RE. Epub 2020 Sep 18. PMID: 32946349. 16: Gura WP, Gelain J, Sikora EJ, Vinson EL, Brannen PM, Schnabel G. Low frequency of resistance to thiophanate-methyl in Monilinia fructicola populations from southeastern United States peach orchards. Pestic Biochem Physiol. 2023 Dec;197:105642. doi: 10.1016/j.pestbp.2023.105642. Epub 2023 Oct 12. PMID: 38072561. 17: Miyamoto T, Hayashi K, Okada R, Wari D, Ogawara T. Resistance to succinate dehydrogenase inhibitors in field isolates of Podosphaera xanthii on cucumber: Monitoring, cross-resistance patterns and molecular characterization. Pestic Biochem Physiol. 2020 Oct;169:104646. doi: 10.1016/j.pestbp.2020.104646. Epub 2020 Jul 4. PMID: 32828365. 18: Muñoz M, Faust JE, Schnabel G. Characterization of Botrytis cinerea From Commercial Cut Flower Roses. Plant Dis. 2019 Jul;103(7):1577-1583. doi: 10.1094/PDIS-09-18-1623-RE. Epub 2019 May 13. PMID: 31082321. 19: Neupane S, Avin FA, Liyanapathiranage P, Simmons T, Baysal-Gurel F. Identification and Chemical and Biological Management of Fusarium Root and Crown Rot Disease of Oakleaf Hydrangea. Plant Dis. 2023 Oct;107(10):3188-3197. doi: 10.1094/PDIS-11-22-2609-RE. Epub 2023 Oct 23. PMID: 36890131. 20: Lee J, Elliott MR, Yamada T, Jung G. Field Assessment of Six Point-Mutations in SDH Subunit Genes Conferring Varying Resistance Levels to SDHIs in Clarireedia spp. Plant Dis. 2021 Jun;105(6):1685-1691. doi: 10.1094/PDIS-06-20-1344-RE. Epub 2021 May 4. PMID: 33944573.