AMDE-1 | CAS#478043-30-0 | autophagy activity modulator

MedKoo Cat#: 562380 | Name: AMDE-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMDE-1 is a modulator of autophagy activity. It acts by triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation.

Chemical Structure

AMDE-1

CAS#478043-30-0

Theoretical Analysis

MedKoo Cat#: 562380

Name: AMDE-1

CAS#: 478043-30-0

Chemical Formula: C18H8ClF6N3

Exact Mass: 415.0311

Molecular Weight: 415.72

Elemental Analysis: C, 52.01; H, 1.94; Cl, 8.53; F, 27.42; N, 10.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AMDE-1; AMDE 1; AMDE1; Autophagy Modulator with Dual Effect-1;

IUPAC/Chemical Name

alpha-(3-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile

InChi Key

QPWWAOMXYPIDOY-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H8ClF6N3/c19-10-3-1-2-9(6-10)12(8-26)14-5-4-11-13(17(20,21)22)7-15(18(23,24)25)28-16(11)27-14/h1-7,12H

SMILES Code

N#CC(C1=CC=CC(Cl)=C1)C2=NC3=NC(C(F)(F)F)=CC(C(F)(F)F)=C3C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 415.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gao Y, Liu Y, Hong L, Yang Z, Cai X, Chen X, Fu Y, Lin Y, Wen W, Li S, Liu X, Huang H, Vogt A, Liu P, Yin XM, Li M. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330. doi: 10.1038/cddis.2016.236. PubMed PMID: 27512951; PubMed Central PMCID: PMC5108321. 2: Li M, Yang Z, Vollmer LL, Gao Y, Fu Y, Liu C, Chen X, Liu P, Vogt A, Yin XM. AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One. 2015 Apr 20;10(3):e0122083. doi: 10.1371/journal.pone.0122083. eCollection 2015. PubMed PMID: 25894744; PubMed Central PMCID: PMC4403922.