Y-134 | CAS#849662-80-2 | Oestrogen receptor (ER) modulator (SERM)

MedKoo Cat#: 556220 | Name: Y-134

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Y-134 is a selective estrogen receptor modulator (SERM) with high affinity for ERα (Ki = 0.09 nM) over ERβ (Ki = 11.31 nM). It acts as an agonist in bone tissue and an antagonist in reproductive tissues, effectively inhibiting estrogen-stimulated proliferation of ER-positive breast cancer cells. Y-134 exhibits no cross-reactivity with other steroid hormone receptors, including mineralocorticoid, glucocorticoid, androgen, and progesterone receptors.

Chemical Structure

Y-134

CAS#849662-80-2

Theoretical Analysis

MedKoo Cat#: 556220

Name: Y-134

CAS#: 849662-80-2

Chemical Formula: C28H28N2O3S

Exact Mass: 472.1821

Molecular Weight: 472.60

Elemental Analysis: C, 71.16; H, 5.97; N, 5.93; O, 10.16; S, 6.78

Price and Availability

Size	Price	Availability
50mg	USD 950.00	2 Weeks
100mg	USD 1,650.00	2 Weeks
200mg	USD 2,950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Y-134; Y 134; Y134;

IUPAC/Chemical Name

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone

InChi Key

LQEOPHGPHCWOAC-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H28N2O3S/c1-18(2)29-13-15-30(16-14-29)21-7-3-19(4-8-21)27(33)26-24-12-11-23(32)17-25(24)34-28(26)20-5-9-22(31)10-6-20/h3-12,17-18,31-32H,13-16H2,1-2H3

SMILES Code

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(N5CCN(C(C)C)CC5)C=C4

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 472.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xing M, Liu H, Tong L, Duan H, Yan X. Learning curve for double micro-portal video-assisted thoracoscopic lobectomy. J Thorac Dis. 2025 Jan 24;17(1):379-389. doi: 10.21037/jtd-24-1000. Epub 2025 Jan 22. PMID: 39975714; PMCID: PMC11833562. 2: Kesse-Guyot E, Rebouillat P, Payrastre L, Allès B, Fezeu LK, Druesne-Pecollo N, Srour B, Bao W, Touvier M, Galan P, Hercberg S, Lairon D, Baudry J. Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study. Int J Behav Nutr Phys Act. 2020 Nov 9;17(1):136. doi: 10.1186/s12966-020-01038-y. PMID: 33167995; PMCID: PMC7653706. 3: Dimaano NGB, Ali J, Mahender A, Sta Cruz PC, Baltazar AM, Diaz MGQ, Pang YL, Acero BL Jr, Li Z. Identification of quantitative trait loci governing early germination and seedling vigor traits related to weed competitive ability in rice. Euphytica. 2020;216(10):159. doi: 10.1007/s10681-020-02694-8. Epub 2020 Sep 19. PMID: 33029032; PMCID: PMC7510932. 4: Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 Jun 14;294(24):9461-9475. doi: 10.1074/jbc.RA119.008697. Epub 2019 May 9. PMID: 31073029; PMCID: PMC6579480. 5: Tepper PG, Liu X, Hamilton M, Mardekian J, Petkun W, Tan W, Singer DE. Ischemic Stroke in Nonvalvular Atrial Fibrillation at Warfarin Initiation: Assessment via a Large Insurance Database. Stroke. 2017 Jun;48(6):1487-1494. doi: 10.1161/STROKEAHA.116.015535. Epub 2017 Apr 26. Erratum in: Stroke. 2017 Aug;48(8):e239. doi: 10.1161/STR.0000000000000138. PMID: 28446621. 6: Fons-Castells J, Tent-Petrus J, Llauradó M. Simultaneous determination of specific alpha and beta emitters by LSC-PLS in water samples. J Environ Radioact. 2017 Jan;166(Pt 1):195-201. doi: 10.1016/j.jenvrad.2016.04.035. Epub 2016 May 5. PMID: 27156160. 7: Mathieu J, Schloendorn J, Rittmann BE, Alvarez PJ. Microbial degradation of 7-ketocholesterol. Biodegradation. 2008 Nov;19(6):807-13. doi: 10.1007/s10532-008-9183-5. Epub 2008 Mar 15. PMID: 18344006. 8: Isobe K, Mori N, Wakao N. The second cholesterol oxidase produced by gamma- proteobacterium Y-134. J Biosci Bioeng. 2003;96(3):257-61. doi: 10.1016/s1389-1723(03)80190-1. PMID: 16233518. 9: Isobe K, Shoji K, Nakanishi Y, Yokoe M, Wakao N. Purification and some properties of cholesterol oxidase stable in detergents from gamma- proteobacterium Y-134. J Biosci Bioeng. 2003;95(3):257-63. doi: 10.1016/s1389-1723(03)80026-9. PMID: 16233402. 10: Barichella M, Marczewska A, Vairo A, Canesi M, Pezzoli G. Is underweightness still a major problem in Parkinson's disease patients? Eur J Clin Nutr. 2003 Apr;57(4):543-7. doi: 10.1038/sj.ejcn.1601581. PMID: 12700615. 11: Acosta Bas C, Baluja Conde IB, Brito Moreno AI, Rodríguez López MR, Melchor A, Hernández L, Frómeta A, Selles ME, Martínez L. Monoclonal antibody against human trypsin: production, characterization, and use for diagnosis. Hybrid Hybridomics. 2002 Dec;21(6):487-90. doi: 10.1089/153685902321044025. PMID: 12573113. 12: Baluja Conde IB, Brito Moreno AI, Acosta Bas C, Zalueta Rodríguez O, Melchor Rodríguez A, Amores Sanchéz I, Martínez L, Hernández M. Monoclonal antibody against free beta-subunit of human chorionic gonadotropin. Hybrid Hybridomics. 2002 Oct;21(5):381-4. doi: 10.1089/153685902761022733. PMID: 12470481. 13: Acosta Bas C, Baluja Conde IB, Brito Moreno AI, Rodriguez Lopez MR, Melchor A, Hernandez L, Frómeta A. Specific monoclonal antibody against human trypsin. Hybrid Hybridomics. 2002 Aug;21(4):307-10. doi: 10.1089/153685902760213930. PMID: 12193285. 14: Paulij WP, de Wit PLM, Sünnen CMG, van Roosmalen MH, Petersen-van Ettekoven A, Cooreman MP, Heijtink RA. Localization of a unique hepatitis B virus epitope sheds new light on the structure of hepatitis B virus surface antigen. J Gen Virol. 1999 Aug;80 ( Pt 8):2121-2126. doi: 10.1099/0022-1317-80-8-2121. PMID: 10466811.