SZM594 is a PIPK3 inhibitor. SZM594 showed to be more potent in the HT29 cellular necroptosis assay (EC50 = 0.44 μM vs 1.44 μM), displayed reduced cytotoxicity (CC50 > 50 μM vs 36.5 μM), had greater affinity for RIPK3 (KD = 81 nM) and selectivity over RIPK1 (KD > 5,000 nM) in the KINOMEscan assay.
MedKoo Cat#: 122756
Name: SZM594
CAS#: N/A
Chemical Formula: C26H19F4N3O3S
Exact Mass: 529.1100
Molecular Weight: 529.51
Elemental Analysis: C, 58.98; H, 3.62; F, 14.35; N, 7.94; O, 9.06; S, 6.05
The following data is based on the product molecular weight 529.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
