QX77 | CAS#1798331-92-6 | (CMA) activator| MedKoo

MedKoo Cat#: 565625 | Name: QX77

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QX77 is a novel chaperone-mediated autophagy (cma) activator, dysregulating the repressive function of retinoic acid receptor-alpha over the cma machinery, inducing the significant upregulation of megalin expression in cystinotic ptcs, rescuing the defective trafficking phenotype in ctns-ko ptcs thus favoring a net and significant increment in rab11 transpor

Chemical Structure

QX77

CAS#1798331-92-6

Theoretical Analysis

MedKoo Cat#: 565625

Name: QX77

CAS#: 1798331-92-6

Chemical Formula: C16H13ClN2O2

Exact Mass: 300.0666

Molecular Weight: 300.74

Elemental Analysis: C, 63.90; H, 4.36; Cl, 11.79; N, 9.31; O, 10.64

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 2,950.00	2 Weeks
2g	USD 5,250.00	2 Weeks

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Related CAS #

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Synonym

QX77; QX 77; QX-77

IUPAC/Chemical Name

N-[4-(7-Chloro-2H-1,4-benzoxazin-3-yl)phenyl]acetamide

InChi Key

PYCTUCLCTVWILY-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-8H,9H2,1H3,(H,18,20)

SMILES Code

CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 can impede self-renewal and promote differentiation of ES cells.

In vitro activity:

To be determined

In vivo activity:

Diabetic retinopathy is one of the leading causes of blindness in the world. GMFB antibody, QX77, NKH477, and Liproxstatin-1 were all effective in preventing early diabetic retinopathy and maintaining normal visual function. Reference: Redox Biol. 2022 Jun;52:102292. https://pubmed.ncbi.nlm.nih.gov/35325805/

	Solvent	mg/mL	mM
Solubility
	DMSO	15.0	49.88

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 300.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biol. 2022 Jun;52:102292. doi: 10.1016/j.redox.2022.102292. Epub 2022 Mar 18. PMID: 35325805; PMCID: PMC8942824. 2. Ren Y, Cui Q, Zhang J, Liu W, Xu M, Lv Y, Wu Z, Zhang Y, Wu R. Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress-Induced Chaperone-Mediated Autophagy in Mice. Front Pharmacol. 2021 Aug 5;12:707259. doi: 10.3389/fphar.2021.707259. PMID: 34421598; PMCID: PMC8375434.

In vitro protocol:

To be determined

In vivo protocol:

1: Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biol. 2022 Jun;52:102292. doi: 10.1016/j.redox.2022.102292. Epub 2022 Mar 18. PMID: 35325805; PMCID: PMC8942824. 2: Pan ZF, Li SY, Li L, Zhang Y, Hua ZY. 分子伴侣介导的自噬对胆红素诱导的小鼠小胶质细胞损伤的影响 [Impact of chaperone-mediated autophagy on bilirubin-induced damage of mouse microglial cells]. Zhongguo Dang Dai Er Ke Za Zhi. 2024 Apr 15;26(4):385-393. Chinese. doi: 10.7499/j.issn.1008-8830.2312014. PMID: 38660903; PMCID: PMC11057293. 3: Ren Y, Cui Q, Zhang J, Liu W, Xu M, Lv Y, Wu Z, Zhang Y, Wu R. Milk Fat Globule-EGF Factor 8 Alleviates Pancreatic Fibrosis by Inhibiting ER Stress- Induced Chaperone-Mediated Autophagy in Mice. Front Pharmacol. 2021 Aug 5;12:707259. doi: 10.3389/fphar.2021.707259. PMID: 34421598; PMCID: PMC8375434. 4: Rahman F, Johnson JL, Ait Kbaich M, Meneses-Salas E, Shukla A, Chen D, Kiosses WB, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD. Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis. Mol Cell Biol. 2024;44(12):577-589. doi: 10.1080/10985549.2024.2410814. Epub 2024 Oct 22. PMID: 39434668; PMCID: PMC11583627. 5: Du P, Xu X, Wang Y. Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy. Biochem Biophys Res Commun. 2023 Oct 20;678:186-192. doi: 10.1016/j.bbrc.2023.08.048. Epub 2023 Aug 24. PMID: 37643536.