QXG-6442 is a potent and selective CK1α molecular glue Degrader. QXG-6442 demonstrates high proteome-wide selectivity and robust CK1α degradation capacity. QXG-6442 exhibited DC50= 5.7 nM and a Dmax of 90% in MOLT-4 cells after 5 hours of treatment at 1 µM. QXG-6442 selectively targets CK1α without affecting other CRBN neosubstrates. CK1α degradation by QXG-6442 was rescued in CRBN-knockout cells, confirming its CRBN dependency.
MedKoo Cat#: 128393
Name: QXG-6442
CAS#: N/A
Chemical Formula: C21H17N5O4
Exact Mass: 403.1281
Molecular Weight: 403.40
Elemental Analysis: C, 62.53; H, 4.25; N, 17.36; O, 15.86
The following data is based on the product molecular weight 403.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
