Synonym
p38MAP modulator, p38MAPmodulator
IUPAC/Chemical Name
3-[5-Chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoic acid
InChi Key
GEFBZDGWNJSLQF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H13ClF2N2O4/c1-10-2-3-11(19(26)27)6-15(10)24-9-23-17(16(20)18(24)25)28-8-12-4-5-13(21)7-14(12)22/h2-7,9H,8H2,1H3,(H,26,27)
SMILES Code
O=C(O)C1=CC=C(C)C(N(C=NC(OCC2=CC=C(F)C=C2F)=C3Cl)C3=O)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
406.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen T, Zhang WW, Chu YX, Wang YQ. Acupuncture for Pain Management: Molecular Mechanisms of Action. Am J Chin Med. 2020;48(4):793-811. doi: 10.1142/S0192415X20500408. Epub 2020 May 15. PMID: 32420752.
2: Koul HK, Pal M, Koul S. Role of p38 MAP Kinase Signal Transduction in Solid Tumors. Genes Cancer. 2013 Sep;4(9-10):342-59. doi: 10.1177/1947601913507951. PMID: 24349632; PMCID: PMC3863344.
3: Topolska-Woś AM, Rosińska S, Filipek A. MAP kinase p38 is a novel target of CacyBP/SIP phosphatase. Amino Acids. 2017 Jun;49(6):1069-1076. doi: 10.1007/s00726-017-2404-7. Epub 2017 Mar 10. PMID: 28283909; PMCID: PMC5437258.
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5: Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, Kong IK, Chang KT, Lee DS. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways. Neurosci Lett. 2015 Jan 1;584:191-6. doi: 10.1016/j.neulet.2014.10.016. Epub 2014 Oct 22. PMID: 25459294.
6: Park EC, Rongo C. The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. Elife. 2016 Jan 5;5:e12010. doi: 10.7554/eLife.12010. PMID: 26731517; PMCID: PMC4775213.
7: Tanaka H, Sawano T, Konishi N, Harada R, Takeuchi C, Shin Y, Sugiura H, Nakatani J, Fujimoto T, Yamagata K. Serotonin induces Arcadlin in hippocampal neurons. Neurosci Lett. 2020 Mar 16;721:134783. doi: 10.1016/j.neulet.2020.134783. Epub 2020 Jan 22. PMID: 31981722.
8: Nakamura M, Chikama T, Nishida T. Participation of p38 MAP kinase, but not p44/42 MAP kinase, in stimulation of corneal epithelial migration by substance P and IGF-1. Curr Eye Res. 2005 Oct;30(10):825-34. doi: 10.1080/02713680591006129. PMID: 16251119.
9: Khatiwada S, Delhon G, Chaulagain S, Rock DL. The novel ORFV protein ORFV113 activates LPA-p38 signaling. PLoS Pathog. 2021 Oct 6;17(10):e1009971. doi: 10.1371/journal.ppat.1009971. PMID: 34614034; PMCID: PMC8523077.
10: Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG. p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability. J Clin Invest. 2001 Nov;108(10):1495-504. doi: 10.1172/JCI12190. PMID: 11714741; PMCID: PMC209415
