ZUH280 is a potent and effective HDAC8 Degrader. SZUH280 effectively induced HDAC8 protein degradation and inhibited cancer cell growth even at low micromolar concentrations. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization. In mice, a single SZUH280 dose induced rapid and prolonged HDAC8 protein degradation in xenograft tumor tissues. Moreover, SZUH280 alone or in combination with irradiation resulted in long-lasting tumor regression in an A549 tumor mouse model.
MedKoo Cat#: 122429
Name: ZUH280
CAS#: N/A
Chemical Formula: C36H34N8O8
Exact Mass: 706.2500
Molecular Weight: 706.72
Elemental Analysis: C, 61.18; H, 4.85; N, 15.86; O, 18.11
The following data is based on the product molecular weight 706.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
