6-(3-hydroxypropylamino)hexyl 2-hexyldecanoate, also known as RUN12314, is an amino ionizable lipid which can be used to make ALC-0315. The ethanolamine lipid head enhances encapsulation of mRNA. The lipid has identical ester bonds located adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.
MedKoo Cat#: 122379
Name: RUN12314
CAS#: 2795212-31-4
Chemical Formula: C25H51NO3
Exact Mass: 413.3869
Molecular Weight: 413.69
Elemental Analysis: C, 72.59; H, 12.43; N, 3.39; O, 11.60
The following data is based on the product molecular weight 413.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
