Halobetasol propionate is a highly potent synthetic corticosteroid used topically for inflammatory skin conditions such as psoriasis and eczema. It exhibits strong anti-inflammatory, antipruritic, and vasoconstrictive properties, primarily through agonism of the glucocorticoid receptor (GR). In vitro studies show that halobetasol binds GR with high affinity (IC₅₀ ≈ 0.4–0.8 nM), surpassing the potency of other corticosteroids like clobetasol. It suppresses pro-inflammatory cytokine expression, including IL-1β, IL-6, and TNF-α, in keratinocytes and fibroblasts. In vivo, halobetasol demonstrates rapid onset of action and marked reduction in erythema and plaque thickness in psoriatic models.
MedKoo Cat#: 315225
Name: Halobetasol propionate
CAS#: 66852-54-8
Chemical Formula: C22H27ClF2O4
Exact Mass: 428.1566
Molecular Weight: 428.90
Elemental Analysis: C, 61.61; H, 6.35; Cl, 8.27; F, 8.86; O, 14.92
The following data is based on the product molecular weight 428.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
