Synonym
S-(−)-SKF-38393 hydrochloride, S-(−)-SKF-38393 HCl
IUPAC/Chemical Name
(S)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
InChi Key
YEWHJCLOUYPAOH-UQKRIMTDSA-N
InChi Code
1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m0./s1
SMILES Code
OC1=C(O)C=C2[C@H](C3=CC=CC=C3)CNCCC2=C1.[H]Cl
Appearance
Tan solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2933.99.7900
Preparing Stock Solutions
The following data is based on the
product
molecular weight
291.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Carlson, J. H., Bergstrom, D. A., Weick, B. G., & Walters, J. R. (1987). Neurophysiological investigation of effects of the D‐1 agonist SKF 38393 on tonic activity of substantia nigra dopamine neurons. Synapse, 1(5), 411-416.
Inoue, K., Nakazawa, K., Watano, T., Ohara-Imaizumi, M., Fujimori, K., & Takanaka, A. (1992). Dopamine receptor agonists and antagonists enhance ATP-activated currents. European journal of pharmacology, 215(2-3), 321-324.
Sun, W., & Salvi, R. J. (2001). Dopamine modulates sodium currents in cochlear spiral ganglion neurons. Neuroreport, 12(4), 803-807.
-SKF-38393 HCl.jpg "S-(−)-SKF-38393 HCl")
