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MedKoo Cat#: 124501 | Name: Utibapril

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Utibapril (FPL 63547) is an ester prodrug of a novel thiadiazoline ACE inhibitor.

Chemical Structure

Utibapril
Utibapril
CAS#109683-61-6

Theoretical Analysis

MedKoo Cat#: 124501

Name: Utibapril

CAS#: 109683-61-6

Chemical Formula: C22H31N3O5S

Exact Mass: 449.2000

Molecular Weight: 449.57

Elemental Analysis: C, 58.78; H, 6.95; N, 9.35; O, 17.79; S, 7.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
FPL 63547; Utibapril; 109683-61-6; Utibaprilo; Utibaprilum; Utibapril [INN:BAN]
IUPAC/Chemical Name
5-(tert-butyl)-3-((1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl)-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid
InChi Key
FTYVYAGWBXTWTN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H31N3O5S/c1-6-30-20(29)16(13-12-15-10-8-7-9-11-15)23-14(2)17(26)25-18(19(27)28)31-21(24-25)22(3,4)5/h7-11,14,16,18,23H,6,12-13H2,1-5H3,(H,27,28)
SMILES Code
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(SC(=N2)C(C)(C)C)C(=O)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 449.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Buikema H, Pinto YM, van Geel PP, Rooks G, de Langen CD, de Graeff PA, van Gilst WH. Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. doi: 10.1097/00005344-199705000-00018. PMID: 9213213. 2: Carr RD, Higgs L, Killingback PG, Nicol AK, O'Connor SE, Robson A, Wells E, Simpson WT. Pharmacological properties of FPL 63547, a novel inhibitor of angiotensin-converting enzyme. Br J Pharmacol. 1990 May;100(1):83-9. doi: 10.1111/j.1476-5381.1990.tb12056.x. PMID: 2164863; PMCID: PMC1917465. 3: Carr RD, Cooper AE, Hutchinson R, Mann J, O'Connor SE, Robinson DH, Wells E. Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin- converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4. doi: 10.1111/j.1476-5381.1990.tb12057.x. PMID: 2164864; PMCID: PMC1917479.