LN6023 | CAS# 1086713-00-9 | ACKR3/CXCR7 Superagonist

MedKoo Cat#: 121126 | Name: LN6023

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thrombosis.

Chemical Structure

LN6023

CAS#1086713-00-9 (free base)

Theoretical Analysis

MedKoo Cat#: 121126

Name: LN6023

CAS#: 1086713-00-9 (free base)

Chemical Formula: C20H32N6O2S

Exact Mass: 420.2307

Molecular Weight: 420.58

Elemental Analysis: C, 57.12; H, 7.67; N, 19.98; O, 7.61; S, 7.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

LN6023 2HCl 1086713-00-9 (free base)

Synonym

LN6023; LN-6023; LN 6023

IUPAC/Chemical Name

N-(tert-butyl)-1-(3-((7-ethyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)amino)propyl)piperidine-4-carboxamide

InChi Key

JUYRBVWTTFJCFX-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H32N6O2S/c1-5-15-13-16(27)26-19(22-15)29-18(24-26)21-9-6-10-25-11-7-14(8-12-25)17(28)23-20(2,3)4/h13-14H,5-12H2,1-4H3,(H,21,24)(H,23,28)

SMILES Code

CC(C)(C)NC(C(CC1)CCN1CCCNC2=NN3C(C=C(CC)N=C3S2)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Bayrak A, Mohr F, Kolb K, Szpakowska M, Shevchenko E, Dicenta V, Rohlfing AK, Kudolo M, Pantsar T, Günther M, Kaczor AA, Poso A, Chevigné A, Pillaiyar T, Gawaz M, Laufer SA. Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. J Med Chem. 2022 Sep 23. doi: 10.1021/acs.jmedchem.2c01198. Epub ahead of print. PMID: 36150079.