YF-135 | CAS# | PROTAC

MedKoo Cat#: 121017 | Name: YF-135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YF-135 is a PROTAC with irreversible covalent ligands for the target KARS G12C. YF-135 also attenuates pERK signaling in H358 and H23 cells in a reversible manner.

Chemical Structure

YF-135

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 121017

Name: YF-135

CAS#: Unknown

Chemical Formula: C64H78ClN11O6S

Exact Mass: 1163.5546

Molecular Weight: 1164.91

Elemental Analysis: C, 65.99; H, 6.75; Cl, 3.04; N, 13.23; O, 8.24; S, 2.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

YF-135; YF135; YF 135

IUPAC/Chemical Name

(2S,4R)-1-((2S)-2-(3-(3-((2S)-2-(((7-(8-chloronaphthalen-1-yl)-4-((2R)-1-((E)-2-cyano-3-cyclopropylacryloyl)-2-(cyanomethyl)piperidin-4-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key

IZYZGCLLHCJKKQ-XWKKFEMTSA-N

InChi Code

InChI=1S/C64H78ClN11O6S/c1-41-60(83-40-69-41)45-18-16-43(17-19-45)35-68-61(79)55-33-50(77)36-75(55)38-56(64(2,3)4)71-57(78)23-30-81-29-8-26-73-25-7-11-49(73)39-82-63-70-53-37-74(54-13-6-10-44-9-5-12-52(65)58(44)54)27-22-51(53)59(72-63)46-21-28-76(48(32-46)20-24-66)62(80)47(34-67)31-42-14-15-42/h5-6,9-10,12-13,16-19,31,40,42,46,48-50,55-56,77H,7-8,11,14-15,20-23,25-30,32-33,35-39H2,1-4H3,(H,68,79)(H,71,78)/b47-31+/t46?,48-,49-,50+,55-,56+/m0/s1

SMILES Code

O=C(N[C@@H](C(C)(C)C)CN1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)CCOCCCN4CCC[C@H]4COC5=NC(C6CCN(C(/C(C#N)=C/C7CC7)=O)[C@@H](CC#N)C6)=C(CCN(C8=CC=CC9=C8C(Cl)=CC=C9)C%10)C%10=N5

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,164.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Yang F, Wen Y, Wang C, Zhou Y, Zhou Y, Zhang ZM, Liu T, Lu X. Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022 Feb 15;230:114088. doi: 10.1016/j.ejmech.2021.114088. Epub 2022 Jan 3. PMID: 35007863.