Zanoterone | CAS#107000-34-0 | AR Antagonist

MedKoo Cat#: 150166 | Name: Zanoterone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zanoterone is a steroidal androgen receptor antagonist that was studied for the treatment of benign prostatic hyperplasia.

Chemical Structure

Zanoterone

CAS#107000-34-0

Theoretical Analysis

MedKoo Cat#: 150166

Name: Zanoterone

CAS#: 107000-34-0

Chemical Formula: C23H32N2O3S

Exact Mass: 416.2130

Molecular Weight: 416.58

Elemental Analysis: C, 66.31; H, 7.74; N, 6.72; O, 11.52; S, 7.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Zanoterone; Win 49,596; WIN-49596; WIN 49596; WIN49596; XQ5V1W49JG;

IUPAC/Chemical Name

(1S,2S,10S,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-6-methylsulfonyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4,7-dien-17-ol

InChi Key

MHDDZDPNIDVLNK-ZGIWMXSJSA-N

InChi Code

1S/C23H32N2O3S/c1-5-23(26)11-9-19-17-7-6-16-12-20-15(14-25(24-20)29(4,27)28)13-21(16,2)18(17)8-10-22(19,23)3/h1,14,16-19,26H,6-13H2,2-4H3/t16-,17+,18-,19-,21-,22-,23-/m0/s1

SMILES Code

O[C@@]1(C#C)CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CC5=NN(S(=O)(C)=O)C=C5C[C@]4(C)[C@@]3([H])CC[C@]12C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 416.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Juniewicz PE, Hoekstra SJ, Lemp BM, Barbolt TA, Devin JA, Gauthier E, Frenette G, Dube JY, Tremblay RR. Effect of combination treatment with zanoterone (WIN 49596), a steroidal androgen receptor antagonist, and finasteride (MK-906), a steroidal 5 alpha-reductase inhibitor, on the prostate and testes of beagle dogs. Endocrinology. 1993 Aug;133(2):904-13. doi: 10.1210/endo.133.2.8393778. PMID: 8393778. 2: Berger BM, Naadimuthu A, Boddy A, Fisher HA, McConnell JD, Milam D, Mobley D, Rajfer J. The effect of zanoterone, a steroidal androgen receptor antagonist, in men with benign prostatic hyperplasia. The Zanoterone Study Group. J Urol. 1995 Sep;154(3):1060-4. PMID: 7543598. 3: Roberts AE, Ritz MA, Hoekstra S, Descotes G, Hincks JR. Induction of liver cytochrome P-450 (CYP) 3A in male and female rats by a steroidal androgen receptor antagonist, zanoterone. J Biochem Toxicol. 1996;11(3):101-10. doi: 10.1002/(SICI)1522-7146(1996)11:3<101::AID-JBT1>3.0.CO;2-O. PMID: 9029268.