L 669262 | CAS#130468-11-0 | HMG-CoA reductase inhibitor

MedKoo Cat#: 596620 | Name: L 669262

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 669262, also known as 6-Oxo Simvastatin, is a potent HMG-CoA reductase inhibitor.

Chemical Structure

L 669262

CAS#130468-11-0

Theoretical Analysis

MedKoo Cat#: 596620

Name: L 669262

CAS#: 130468-11-0

Chemical Formula: C25H36O6

Exact Mass: 432.2512

Molecular Weight: 432.56

Elemental Analysis: C, 69.42; H, 8.39; O, 22.19

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Related CAS #

No Data

Synonym

L 669262; L-669262; L669262; L-669,262; L 669,262; L669,262; 6-Oxo Simvastatin; 6-Oxo degradate;

IUPAC/Chemical Name

(1S,7R,8R,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-6-oxo-1,2,6,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate

InChi Key

NPDFVGFXQSJBAA-ZBDDBYLNSA-N

InChi Code

InChI=1S/C25H36O6/c1-6-25(4,5)24(29)31-21-10-14(2)9-16-11-20(27)15(3)19(23(16)21)8-7-18-12-17(26)13-22(28)30-18/h9,11,15,17-19,21,23,26H,6-8,10,12-13H2,1-5H3/t15-,17-,18-,19+,21+,23+/m1/s1

SMILES Code

CCC(C)(C)C(O[C@H]1CC(C)=CC2=CC([C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L 669262 is a potent HMG-CoA reductase inhibitor.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 432.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Joshua H, Schwartz MS, Wilson KE. L-669,262, a potent HMG-CoA reductase inhibitor. J Antibiot (Tokyo). 1991 Mar;44(3):366-70. PubMed PMID: 2026562.